Automated Large-Scale Genome Scanning and Linkage Analysis Strategy of Genetic Disease Related Gene Location
Journal Title: Genetic Disease Study - Year 2018, Vol 2, Issue 1
Abstract
With the development of the Human Genome Project, many methods have been applied in this field. Since the 1990s, large-scale scanning and mapping of base circles have been established and developed by combining linkage analysis with automation in genomes. At present, it has become the most widely used and effective means in this field.
Authors and Affiliations
Lawrence Noyes, Chiara Palacios, Reginald Finn
Research Progress of Notch Signaling Pathway Related Diseases
Notch signal transduction pathway is one of the important pathways that affect the fate of cells. Adjacent cells transmit signals through Notch receptors to regulate the differentiation, proliferation and apoptosis of ma...
Automated Large-Scale Genome Scanning and Linkage Analysis Strategy of Genetic Disease Related Gene Location
With the development of the Human Genome Project, many methods have been applied in this field. Since the 1990s, large-scale scanning and mapping of base circles have been established and developed by combining linkage a...
Application of Phylogenetic Analysis in the Study of Mitochondrial Genetic Diseases
Mitochondrial genetic diseases are receiving increasing attention. However, the common case-control methods are susceptible to genetic background, population stratification, data quality and other factors that may lead t...
The Functional Mechanisms and Clinical Application of Read-Through Drugs
According to previous reports, nearly one in 10 genetic diseases are caused by nonsense mutations around the world. Nonsense mutations lead to premature transcription terminations in cells, which in turn generate non-fun...
Whole Genome Sequencing Progress in Medical Application
At present, there are still a lot of diseases pathogenesis not clear, but making use of a new generation of sequencing technology to organisms conduct whole genome sequencing, which for the pathogenesis of many diseases...