AUTOMATIC POTENTIOMETERIC DETERMINATION OF SOME THIRD GENERATION CEPHALOSPORIN'S ANTIBIOTICS
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2018, Vol 7, Issue 12
Abstract
A rapid potentiometeric method was suggested for determination of micro amounts of a number of third generation cephalosporin in pure as well as in commercial samples. The method based on oxidation of (cefoperazone, ceftazidime, cefotaxime, ceftriaxone) with iodate in acidic medium. An excess of iodate solution was added to different concentration samples of each drug in sulfuric acid medium of (pH= 2-3) with heating for few minutes, followed by boiling for another 5 minutes to expel iodine. The un reacted amount of iodated was determined potentiomery by back titration with Hg(II) using Ag electrode coupled with calomel electrode(SCE). A concentrations ranging of 0.2 to 12 m mol/liter of each drug were determined by this method were found to be sensitive and precise. The method was applied for the micro determination of the suggested drugs alone or in drug mixtures as in pure and in formulated samples.
Authors and Affiliations
Dr. Elgendy Kh.
Keywords
Related Articles
- EP ID EP628234
- DOI -
- Views 131
- Downloads 0
DEVELOPMENT OF NOVEL 2-AMINOBENZOTHIAZOLE DERIVATIVES AS ANTIBACTERIAL AND ANTIFUNGAL AGENTS
In inspection of 2-aminobenzothiazole analogues are of interest due to their extensive diversity of potential activities eligible structures in medicinal chemistry. It containing 2-aminobenzothiazole core nucleus in reac...
PREPARATION AND EVALUATION OF GASTRORETENTIVE SYSTEMS OF TELMISARTAN
Telmisartan (TEL) is a selective angiotensin II receptor blocker used in the management of cardiovascular disorders. It is a class II drug according to biopharmaceutics classification system; with poor solubility and hig...
A REVIEW ON TRANSUNGUAL DRUG DELIVARY SYSTEM
The nail disorders are mainly due to fungal infection. When the drug is given through oral or systemic route, the potency of drugs gets decreased at the site of action. To avoid this loss of drug potency topical route of...
FAP INHIBITORS: IN DIABETIC NEPHROPATHY?
FAP inhibitor increases the endogenous level of FGF-21which may help in various Metabolic disease, Diabetes and Diabetic complication. Animal model have shown FGF-21 has protected renal damage in Diabetic animal model. H...
PHARMACOKINETIC INTERACTION STUDY BETWEEN CLOPIDOGREL AND PHENYTOIN IN HEALTHY MALE RABBITS
Introduction: This study was conducted to investigate the effect of clopidogrel – CYP2 C19 inhibitor on the pharmacokinetics (PK) of phenytoin in healthy male rabbits. The main aim of this study is to determine the PK of...