Autosomal Dominant Polycystic Kidney Disease: At a Glance
Journal Title: Public Health Open Access - Year 2018, Vol 2, Issue 1
Abstract
Polycystic kidney disease (PKD) is a systemic disorder which adds majority of renal patients to end stage renal disease (ESRD). Among all type of PKD, autosomal dominant polycystic kidney disease (ADPKD) is most prevalent and fourth most leading cause of dialysis and kidney transplant. Polycystic kidneys in several genetic and non-genetic disorders suggest the role of multiple factors in cystogenesis. Linkage analysis revealed some closely linked loci two of which are identified as PKD1, PKD2 and an unidentified locus to ADPKD. Candidate gene products are central molecules of proteinprotein complex located at primary cilia and adhesion junctions of cell. In present study, Adult age group 31-59 years patients were more in number and relatively enlarged kidney size was observed in 49 PKD cases. Almost equal incidence of PKD in females to males (48.8%:51.2%) was observed in Indian population. 30.95% of the total cases enrolled cases had positive family history. Two associated symptoms like hypertension and presence of liver cysts and hepatomegaly were found more in frequency 19% and 39% in polycystic patients. Expressivity and variability in symptoms of ADPKD at individual level imply the role of genetic heterogeneity, effect of modifier genes and environmental factors.
Authors and Affiliations
Sonam Raj , Rana Gopal Singh and Parimal Das
Knowledge, Attitudes and Practices Regarding the Use of Traditional Medicine in the Treatment of Malaria among Households in the Buea Health District, Cameroon
Background: Traditional medicine (TM) has maintained its popularity in most developing countries. The use of TM in the treatment of illnesses such as malaria is a common practice that began in pre-historic times. Aim: Th...
Diabetes and its Resulting Complications: Mathematical Modeling via Fractional Calculus
Our main objective in this editorial-cum-mini review article is to briefly outline several recent investigations in which mathematical analytic studies were successfully made of the model of diabetes and its resulting co...
What are the Impact of Season and Temperature Variations in India on the Number of Adolescent/Adult Mortality Due to Heart Disease / Hypertension – A Cross-Sectional Research Study?
One of the researcher of this study who is also a medical doctor with experience of 18 years have suspected that there are season and temperature variations in India on the number of adolescent/adult mortality due to Hea...
Role of Demographic Factors on National Health Insurance Uptake among Informal Sector Workers in Vihiga Sub County, Vihiga County, Kenya: A Cross-Sectional Study
Aim: The aim of the study was to determine the role of demographic factors on uptake of National Health Insurance among the informal sector workers in Vihiga Sub-County. Subject and Methods: The target population for th...
Dengue Behavior in The Face of the Covid-19 Pandemic in Minas Gerais, Brazil
This study analyzes, describes, and differentiates between the measurement of Dengue in Minas Gerais, Brazil, between January 2018 and April 2021, and Covid-19 data reported between March 2020 and April 2021. An epidemio...