AYUR-INFORMATICS: BLOCKING THE TRANSLATION PATHWAY OF FUMARATE HYDRATASE MUTATION GENE BY RNAI TECHNIQUE AND ESTABLISHING AN AYURVEDIC REMEDY FOR UTERINE FIBROIDS
Journal Title: International Journal of Pharmaceutical Applications - Year 2010, Vol 1, Issue 1
Abstract
Fumarate hydratase precursor (mutation) protein of Homo sapiens was taken. Homology modeling studies were done and 3D structure of FH protein was modelled. Ayurvedic herbs Aloe vera, Commiphora mukul, Asparagus racemosa and Saraca indica‘s active components were selected, combined & docked with Fumarate hydratase mutation protein. The docking proves that the combination is effective in curing uterine fibroids. Again, by means of RNAi technique, the translation–pathway of a Fumarate Hydratase mutation gene is blocked.
Authors and Affiliations
Waheeta Hopper, Preenon Bagchi, Hemalatha R.
Keywords
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