AZITHROMYCIN VERSUS CEFTRIAXONE- WHICH IS BETTER IN UNCOMPLICATED TYPHOID FEVER? A CLINICAL TRIAL IN A TERTIARY CARE HOSPITAL
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2019, Vol 8, Issue 17
Abstract
BACKGROUND Enteric fever has been very a common and many times a fatal infective disease found in developing countries and has been known to have increasing resistance to novel drugs. So, there is an urgent need for a simple, therapeutic, cost-effective medicine to treat typhoid fever & to prevent further drug resistance. METHODS It is a non-randomized, case-control study done in Paediatrics department of Dr. Prabhakar Kore Hospital & Research centre of KAHER (KLE Academy of Higher Education and Research), attached to J N Medical College, Belagavi, over a period of 18 months from June 2017 to December 2018. The study included 200 children (2-17 years of age) with positive Widal result, uncomplicatedenteric fever; in this cohort, 100 children were treated using (oral, low dose, for short duration of 6 days) Azithromycin and remaining 100 children were treated with (intravenous, 7 days) Ceftriaxone. Each child was assessed clinically every day, & study results were captured as clinical and microbiological cure or failure, at the end of either drug regimens. This descriptive data was statistically analysed in SPSS-20.0 software. The p-value of <0.05 was taken as significant statistically. RESULTS Periods required by children for responding to drug therapy and to became afebrile i.e., defervescence were significantly (p=0.000) less with Azithromycin receiving group than ceftriaxone receiving group. 95% of children who received azithromycin showed defervescence by 5th day of regimen but, only 29% of children receiving ceftriaxone attained defervescence by 5th day of regimen. There was no microbiological clearance at 10th day in only one case of ceftriaxone trial-group. Significantly (p=0.027) there was early clinical cure in azithromycin trial group as compared to ceftriaxone trial group. The microbiological cure was not comparable in either groups (p=0.135). CONCLUSION At the end we come to the conclusion that oral Azithromycin (10 mg/kg/day, once a day for 6 days) is more efficacious in uncomplicated-typhoid fever management as compared to intravenous ceftriaxone (100 mg/kg/day in 2 divided doses for 7 days) in children and adolescents of 2 to 17 years age group.
Authors and Affiliations
Vishwanath Machakanur, Rohit S
Keywords
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- EP ID EP613528
- DOI 10.14260/jemds/2019/310
- Views 42
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