B cell receptor signaling pathway involved in benign lymphoepithelial lesions of the lacrimal gland
Journal Title: International Journal of Ophthalmology - Year 2017, Vol 10, Issue 5
Abstract
"AIM: To detect the expression of B cell receptor signaling pathway (BCRSP) in lacrimal gland benign lymphoepithelial lesions (LGBLEL). METHODS: Gene microarray was used to compare whole-genome expression in lacrimal gland tissues from LGBLEL patients to tissues from orbital cavernous hemangioma (control tissues). Expression of BCRSP was confirmed by polymerase chain reaction (PCR) and immunohistochemistry. RESULTS: The expression of 22 genes of the BCRSP increased significantly in LGBLEL patients. PCR analysis showed that CD22, CR2, and BTK were all highly expressed in LGBLEL tissues. Immunohistochemical analysis showed that CR2 protein was present in LGBLEL, but CD22 and BTK proteins were negative. CR2, CD22, and BTK were not observed in the orbital cavernous hemangiomas with either PCR or immunohistochemistry. CONCLUSION: BCRSP might be involved in the pathogenesis of LGBLEL."
Authors and Affiliations
Jian-Min Ma
Keywords
Related Articles
- EP ID EP603446
- DOI 10.18240/ijo.2017.05.01
- Views 32
- Downloads 0
The lived experiences of patients undergoing acellular porcine corneal stroma transplantation
To explore the lived experiences of patients undergoing acellular porcine corneal stroma (APCS) transplantation, a descriptive, qualitative design was performed. A purposive sample of 13 patients who underwent APCS trans...
Differential expression of breast cancer-resistance protein, lung resistance protein, and multidrug resistance protein 1 in retinas of streptozotocin-induced diabetic mice
"AIM: To investigate the altering expression profiles of efflux transporters such as breast cancer-resistance protein (BCRP), lung resistance protein (LRP), and multidrug resistance protein 1 (MDR1) at the inner blood-re...
Effect of Qingguang’an II on expressions of OX42 protein and IL-1β mRNA of retinal microglia cells of rats with chronic high intraocular pressure
The study investigated the effects of Qingguang’an II (a Chinese medicinal preparation) on expressions of OX42 protein and interleukin-1β (IL-1β) mRNA of retinal microglia cells of rats with chronic high intraocular pres...
Changes in intraocular pressure after intraocular eye surgery—the influence of measuring technique
"AIM: To investigate the changes in intraocular pressure (IOP) before and after intraocular surgery measured with Goldmann applanation tonometry (GAT) and pascal dynamic contour tonometry (PDCT), and assessed their agree...
Evaluation of outer retinal tubulations in diabetic macular edema underwent anti-VEGF treatment
"AIM: To investigate the incidence and subsequent changes of outer retinal tubulations (ORTs) in diabetic macular edema (DME) underwent anti-vascular endothelial growth factor (VEGF) therapy, and to assess the possibilit...