B7-H4 Expression as a Predictive Biomarker in Human Cervical Cancer Immunotherapy
Journal Title: International Journal of Cancer Studies & Research (IJCR) - Year 2016, Vol 5, Issue 2
Abstract
Over the years Immunotherapy has evolved as a beneficial method in the treatment of cancer through the blockade of immune checkpoint molecules which are up regulated on activated lymphocytes, antigen presenting cells (APC`s) and on tumor cells to down regulate immune cell effector functions. B7-H4, which has been shown to be expressed on cervical cancer, is also associated with the poor prognosis of cervical cancer patients. Blockade of this ligand expressed on cervical cancers can be a novel target for molecular targeted immunotherapy against cervical cancer, which is known as the second most diagnosed malignancy among female worldwide.
Authors and Affiliations
Idowu Temitayo
Keywords
Related Articles
- EP ID EP198250
- DOI 10.19070/2167-9118-16000017
- Views 106
- Downloads 0
Prognostic Value of Artificial Neural Network in Predicting Bladder Cancer Recurrence After BCG Immunotherapy
Background: Artificial neural network (ANN) has been used in medicine to predict either the treatment or the investigative outcomes. The aim of this study was to validate the use of ANN models for predicting recurrence i...
Effect of Substrate Dependent Mushroom Polysaccharide Extracts on IL-7 Up Regulation and Cancer Immunotherapy and, their Probable Mode Of Action
Ethnopharmacological relevance: Fungi have been used in traditional systems both as food and medicine. In China the mushrooms are widely used in Traditional Chinese Medicine (TCM). On one hand residue resulting from medi...
Patient-Centered Outcomes Research In Advanced Stage Lung Cancer: Study Design and Population
Background: In 2013, researchers at the University of Nebraska Medical Center (UNMC) received funding from the Patient-Centered Outcomes Research Institute to establish a study that outlines treatment options for patient...
Kaposi Sarcoma of Spleen in HIV-Negative Patient Detected with F-18 FDG PET/CT
We report a case of Kaposi sarcoma (KS) who presented with unusual clinical features. The unusual clinical features were abscence of detectable HIV, absence of cutaneous lesion and presence of a splenic mass. F-18 FDG PE...
Assessment of fatigue in cancer patients
During the last decade, there has been a growing recognition of the high prevalence of fatigue among cancer patients, its adverse effect on their quality of life, and the need to develop effective interventions to preve...