Bacillus anthracis infections – new possibilities of treatment
Journal Title: Annals of Agricultural and Environmental Medicine - Year 2015, Vol 22, Issue 2
Abstract
[b]Introduction and objective[/b]. [i]Bacillus anthracis[/i] is one of biological agents which may be used in bioterrorism attacks. The aim of this study a review of the new treatment possibilities of anthrax, with particular emphasis on the treatment of pulmonary anthrax. [b]Abbreviated description of the state of knowledge[/b]. Pulmonary anthrax, as the most dangerous clinical form of the disease, is also extremely difficult to treat. Recently, considerable progress in finding new drugs and suitable therapy for anthrax has been achieved, for example, new antibiotics worth to mentioning, levofloxacin, daptomycin, gatifloxacin and dalbavancin. However, alternative therapeutic options should also be considered, among them the antimicrobial peptides, characterized by lack of inducible mechanisms of pathogen resistance. Very promising research considers bacteriophages lytic enzymes against selected bacteria species, including antibiotic-resistant strains. [b]Results[/b]. Interesting results were obtained using monoclonal antibodies: raxibacumab, cAb29 or cocktails of antibodies. The application of CpG oligodeoxynucleotides to boost the immune response elicited by Anthrax Vaccine Adsorbed and CMG2 protein complexes, also produced satisfying therapy results. Furthermore, the IFN-α and IFN-β, PA-dominant negative mutant, human inter-alpha inhibitor proteins and LF inhibitors in combination with ciprofloxacin, also showed very promising results. [b]Conclusions[/b]. Recently, progress has been achieved in inhalation anthrax treatment. The most promising new possibilities include: new antibiotics, peptides and bacteriophages enzymes, monoclonal antibodies, antigen PA mutants, and inter alpha inhibitors applications. In the case of the possibility of bioterrorist attacks, the examination of inhalation anthrax treatment should be intensively continued.
Authors and Affiliations
Dorota Żakowska, Michał Bartoszcze, Marcin Niemcewicz, Agata Bielawska-Drózd, Józef Knap, Piotr Cieślik, Krzysztof Chomiczewski, Janusz Kocik
Keywords
Related Articles
- EP ID EP80943
- DOI -
- Views 133
- Downloads 0
Neuromarkers of anxiety and depression in a patient after neuro-ophthalmic surgery of the meningioma – effect of individually-tailored tDCS and neurofeedback
The aim of the study was to evaluate the effectiveness of individually tailored anodal tDCs/ neurofeedback protocol for the reduction of post-operative depression after a neuroophtalmological operation of the meningioma....
Multidisciplinary treatment of a patient with type 2 diabetes and morbid obesity, or perhaps already a surgical diabetology
Relationships between abdominal obesity and glucose tolerance disorders have been well documented. There are also many reports concerning body weight gain during insulin therapy. On the other hand, there are reports pert...
[i]Legionella spp[/i]., amoebae and not-fermenting Gram negative bacteria in an Italian university hospital water system
[b]Introduction. [/b]In hospital and other health care facilities, contamination of water systems by potentially infectious microorganisms, such as bacteria, viruses and protozoa, is a source of nosocomial infections, wh...
Effectiveness of laparoscopic surgeries in treating infertility related to endometriosis
Introduction. Endometriosis is defined as an illness caused by the presence of foci of endometrial tissue outside the uterine cavity. The illness is found in 5–10% of women at reproductive age. In the group of those suff...
Prediction of biological sensors appearance with ARIMA models as a tool for Integrated Pest Management protocols
[b]Introduction and objectives.[/b] Powdery mildew caused by [i]Uncinula necator[/i] and Downy mildew produced by [i]Plasmopara viticola[/i] are the most common diseases in the North-West Spain vineyards. Knowledge of ai...