BACTERIAL INFECTION OF CARCINOMA IN LIVER DISEASES
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2017, Vol 4, Issue 8
Abstract
The development of cancer is associated with several genetic and environmental factors. In addition, many studies showed an association between the development of cancer and bacterial and viral infections for decades. In this study, we aimed to collect and identify various types of bacterial species isolated from patients diagnosed with hepatic carcinoma using different isolation and identification techniques as a preliminary step towards setting of complete profile and thus an early alarm for all possible bacterial infections associated with liver diseases. 204 blood samples were collected from patients diagnosed by hepatocellular carcinoma attending medical labs from 2014to 2015. Different media types were used for isolation of pathogenic and potential pathogenic bacteria associated with hepatocellular carcinoma. Bacterial isolates were purified by sub-culturing and identified using analytical profile index (API) test kits. Specimens were also subjected to some biochemical tests including liver enzymes, glutamic pyruvic transaminase (GPT), glutamic oxalo acetic transaminase (GOT), alkaline phosphatase (ALP) activities, and albumin and Alfa-fetoprotein (AFP) levels as a tumer marker. Hundreds of bacteria were isolated on different Isolation media; however, the most distinguished species were Staphylococcus aureus, Enterobacter aerogenes, Klebsiella sp and Salmonella typhi confirmed with 16S r RNA technique. Based on these results, hepatocellular carcinoma patients are more susceptible to be infected with these bacterial strains. Further studies on a larger scale are required to can set a clinical profile pointing-out the most probable bacterial strains affecting those patients and the best strategies for prevention and treatment.
Authors and Affiliations
Hanan H. Ahmed
Keywords
Related Articles
- EP ID EP628917
- DOI -
- Views 153
- Downloads 0
EFFECT OF PENTACHLOROPHENOL FROM SAW DUST ON CHOLESTEROL AND SOME REPRODUCTIVE HORMONE LEVELS
Pentachlorophenol (PCP) is an industrial wood preservative. It can be absorbed through the lungs, skin and gastrointestinal tract, the skin being the most significant route. This study determined the serum testosterone,...
EFFICACY OF SELECTED MICROBIAL LARVICIDES ON FIELD-COLLECTED LARVAE OF MOSQUITOES FROM PORT HARCOURT METROPOLIS
The comparative effectiveness of two microbial larvicides: Bacillus thuringiensis var israelensis/Bacillus sphaericus (Bti/Bs) combined and Bacillus thuringiensis var israelensis (Bti) were determined against Culex quinq...
RELATIONSHIP BETWEEN TIME OF ONSET AND THE SIDE IN URETERIC COLIC
Background: Ureteric calculi are a commonly encountered clinical problem with a life time risk of 2-5% in Asian population. Fifty percent of patients have a recurrence of renal colic within 5 years of the first episode....
HYPOALBUMINEMIA ON ADMISSION IS ASSOCIATED WITH INCREASED MORTALITY IN HOSPITALIZED PATIENTS PRESENTING WITH SEPSIS
Background: Hypoalbuminemia has been associated with worse clinical outcomes in a variety of conditions including kidney diseases, heart failure, trauma patients and sepsis. This study was carried out to evaluate admissi...
MORPHOMETRIC EVALUATION OF THE EXTERNAL EAR IN RELATION TO ATTACHMENT PATTERN: A STUDY OF ADULT NIGERIANS RESIDENT IN THE SOUTHERN REGION
There are two configurations of earlobe in humans; attached and unattached earlobe. This study was done to evaluate the morphology of the external ear in relation to attachment pattern and to determine the association be...