Bacterio-Antibiotic Susceptibility Profile in Neonatal Sepsis At A Tertiary Neonatal Care Centre
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 4
Abstract
Neonatal sepsis is defined as a clinical syndrome of bacteremia with systemic signs and symptoms of infection in the first 4 weeks of life. This study was undertaken to determine the bacteriological profile and antibiotic sensitivity patterns of microbial isolates from blood cultures of neonates suspected with neonatal sepsis, in Coimbatore Medical College Hospital. An analysis was conducted on all blood culture reports obtained between 1st of July 2015 to the 31st of December 2015. During the study period, 797 newborns with clinical sepsis were admitted. Blood culture reports were positive in 281 cases ( 35.26%).Out of 281 cases, 109 (38.8%) had early-onset sepsis and 172 (61.2%) had late-onset sepsis.The most frequently isolated organism was Klebsiella pneumoniae (49.47%), Staphylococcus aureus (18.14%) followed by Escherichia coli (13.17%).Best overall sensitivity among Gram-negative isolates was to Imipinem (94.67%) followed by Amikacin (78.73%) and best sensitivity among Gram positive isolates was to Vancomycin(87.75%), followed by Cloxacillin and Ampicillin (around 60%).Out of 281 positive cultures, 18 were multi-drug resistant. Conventionally used antibiotic for neonatal sepsis at various centres like cefotaxime , seems to be least useful. Multidrug resistant (ESBL) Gram Negative organisms prevalence is on the rise which necessitates surveillance. Prevalence rate of GBS (Group B Streptococci) is underestimated in developing countries.
Authors and Affiliations
Dr. Senthilkumar P, Dr. Kumar N, Dr. Jayaprakash S
Keywords
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- EP ID EP595487
- DOI 10.9790/0853-160408143147.
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