Bacteriological and Haematological Profile of Neonatal Sepsis in Rural Teaching Hospital in Central India
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 2
Abstract
Aim: This study was aimed to determine the bacteriological profile with their antimicrobial susceptibility as well as haematological profile related to neonatal sepsis. Materials and Methods: In this prospective study conducted during August 2012 to July 2014, the blood samples collected from total 405 newborns suggestive of suspected sepsis were subjected to blood culture and initial sepsis screen. The identification of causative organisms was carried out by standard microbiological tests and antibiotic sensitivity testing as per Clinical Laboratory Standards Institute (CLSI) guidelines. Results: Of the 405 neonates with suspected sepsis, 29.38% had positive blood culture among which Gram negative organisms (68.06%) predominated over Gram positive organisms (31.93%) with Klebsiella species (35.29%) as the commonest bacterial pathogens. Both Gram negative and Gram positive organisms exhibited high to considerable resistance to commonly used antibiotics and found susceptible to meropenem, piperacillintozabactum and cefoperazone-sulbactum, vancomycin, linezolid respectively. The sepsis screen parameters showed varied results among culture positive and culture negative cases. Conclusions: Blood culture as well as sepsis screen should be carried out in neonates suspected of sepsis. The Gram negative bacterial predominance and high to considerable resistance against commonly used antibiotics in the present study makes it necessary to use antibiotics wisely and continuous surveillance to determine the varied pathogen causing neonatal sepsis with their resistance pattern to revise antibiotic policy accordingly
Authors and Affiliations
Vijay C. Ambade
Keywords
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