Bacteriological monitoring of necrobacillosis and means of its specific prevention
Journal Title: Бюлетень "Ветеринарна біотехнологія" - Year 2018, Vol 32, Issue
Abstract
Introduction. To prevent outbreaks and spread of bacterial infections, it is important to have bacteriological monitoring data in order to provide the livestock sector with effective means of specific prevention that can create intense immunity in animals against several of pathogens at once. The goal of the work was to carry out bacteriological monitoring of necrobacillosis in animals and assess the effectiveness of developed and manufactured experimental samples of associated inactivated vaccines against this disease and the main pathogenic bacteria that occurs in microbial associations. Materials and methods. Bacteriological monitoring of necrobacillosis of animals was conducted in Ukrainian farms in 2011-2017 using official statistic data and results of own researches. Earlier we have designed the means of specific prevention against a complicated course of necrobacillosis. Results of research and discussion. The results of bacteriological monitoring according to official statistical data showed that in recent years cattle were infected with necrobacillosis causative agent in 4.6% of cases of all studied biomaterials and 2.1% of all samples tested for bacterial etiology diseases. Analysis of the results of our own bacteriological studies confirmed the associated course of necrobacillosis with unusual clinical manifestations. The species spectrum of the pathogens was represented by E. coli, C. рerfringens type A, B, C, D, various kinds of Salmonella and cocci bacteria that showed symbiotic properties regarding F. necrophorum, since in the presence of their metabolites growth and reproduction of pathogenic fusobacteria were observed. Obtained scientific data were used for the development and production of the associated vaccine Nekrosan and experimental samples of associated vaccines Nekrosan-2, Nekrosalm, Necrocolisalm, Fusoactinosan, which successfully passed laboratory and production tests. Conclusion and prospects further research. The results of bacteriological monitoring of infectious diseases contributed to the determination of priorities in the development of veterinary immunobiological preparations with the relevant species composition of specific antigens, in particular F. necrophorum and other associated bacteria Prospects for further research will be focused on the development of vaccines containing metal nanoparticles.
Authors and Affiliations
Valentina Andriyaschuk, Olga Gorbatiuk, Galina Ryzhenko, Svetlana Tiutiun, Tatyana Ukhovska, Alexander Zhovnir, S. Krylenko
Keywords
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- EP ID EP388886
- DOI 10.31073/vet_biotech32(2)-02
- Views 126
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