Bacteriological Profile and Antibiotic Sensitivity of Organisms Isolated From Neonatal Sepsis at Tertiary Care Hospital
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 3
Abstract
Introduction: As neonatal septicaemia is a life threatening emergency and delays in diagnosis and treatment with appropriate antibiotics may have devastating consequences, surveillance is needed for an ongoing review of the causative organisms and their antibiotic susceptibility pattern. Aims and Objectives: To identify the common pathogens of the disease as well as the antibiotic susceptibility profile of the pathogens in a particular area. Materials and Methods: 170 blood samples were collected from neonates with clinically suspected cases of neonatal sepsis admitted in neonatal intensive care unit (NICU) and special care newborn unit (SCNU), RIMS, Ranchi, between the periods of January 2017 to November 2017. The blood sample was inoculated into BD BACTEC Peds plus culture vial. Positive vials were subjected to gram staining, subculture, and antimicrobial susceptibility test. Results: 75 cases were culture positive among 170 suspected cases. Among culture positive cases there was male predominance (62.7%). Most of the culture positive neonates were preterm i.e. born before 37 weeks (56%). Among the culture positive cases early onset sepsis (64%) was more. Respiratory distress secondary to birth asphyxia was the most common clinical presentation (51.8%). Gram negative bacteria were most common isolate being responsible for 62.7% of cases of septicemia. Klebsiella pneumoniae was found to be the most common isolate followed by CONS (coagulase negative Staphylococcus). Conclusion: The antibiotic abuse has resulted in confusion in diagnosis and the emergence of drug resistant bacterial strains in the nurseries with grave sequelae. Proper hand washing and aseptic obstetric procedures, high incidence of suspicion, prompt diagnosis, aggressive management of sepsis and timely identifying high risk factors can help to prevent neonatal sepsis.
Authors and Affiliations
Versha Priyadarshini, Amber Prasad, Ashok Kumar Sharma, Manoj Kumar, Megha Priyadarshini, Kumari Seema
Keywords
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- EP ID EP531945
- DOI 10.21276/ijmrp.2018.4.3.026
- Views 73
- Downloads 0
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