Bacteriological profile and antibiotic susceptibility patterns in neonatal septicemia in view of emerging drug resistance
Journal Title: Journal of Medical and Allied Sciences - Year 2014, Vol 4, Issue 1
Abstract
The objective of this study was to isolate pathogenic bacteria in neonatal septicaemia cases, and to know their antibiograms. Under aseptic precautions, blood was drawn from 140 neonates with suspected septicaemia and inoculated in BHI broth. Isolates obtained were identified as per standard protocol and antibiotic susceptibility was done by Kirby Bauer disc diffusion method (as per CLSI guidelines). A total number of 62 (44.2%) patients had positive blood cultures. The most common pathogens isolated were Klebsiella pneumoniae (n=22, 35%) followed by Staphylococcus aureus (n=15, 24.1%), Escherichia coli (n=14, 22.5%), CONS (n=7, 11.2%) and Pseudomonas aeruginosa (n=4, 6.4%). The Gram negative organisms showed high resistance to commonly used antibiotics and were highly sensitive to Meropenem. The Gram positive bacteria showed high resistance to Ampicillin, Erythromycin and Amoxycillin; but they were highly susceptible to Linizolid and Vancomycin. As the Gram negative organisms were the most common isolates in neonatal septicaemia, their resistance pattern should be considered essential for deciding the empirical treatment. Prompt treatment of neonatal sepsis with judicious use of appropriate antibiotics can minimize the morbidity and mortality, besides reducing the emergence of multi-drug resistant organisms in ICU’s.
Authors and Affiliations
Maimoona Mustafa | Department of Microbiology, Deccan College of Medical Sciences, Kanchanbagh, Hyderabad-500058, Andhra Pradesh, India, Syed Laeeq Ahmed| Department of Microbiology, Deccan College of Medical Sciences, Kanchanbagh, Hyderabad-500058, Andhra Pradesh, India
Keywords
Related Articles
- EP ID EP12700
- DOI -
- Views 376
- Downloads 24
Simultaneous detection of Hepatitis B virus and Hepatitis C virus in human plasma using Taq-man chemistry
Designing a rapid, reliable and sensitive assay, for detection of hepatitis B virus and Hepatitis C virus variants by real-time PCR, is challenging at best. A recent approach for quantifying the viral load using the s...
Comparative study of risk factors and lipid profile pattern in ischemic and haemorrhagic stroke
Stroke is a devastating and disabling cerebrovascular disease with significant amount of residual deficit leading on economic loss. Creating awareness on common risk factors will reduce the incidence of stroke. The stu...
Diabetes mellitus the ‘Silent Killer’ of mankind: An overview on the eve of upcoming World Health Day!
A rare case of multiple intussusceptions in Peutz–Jeghers syndrome
Peutz–Jeghers syndrome is a rare autosomal dominant genetic disorder characterized by the development of benign hamartomatous polyps in the gastrointestinal tract and hyperpigmented macules on the lips and oral mucosa...
Critical review of hypercalcemia
Hypercalcemia is a clinical condition with an abnormally high serum calcium (Ca) level. Hypercalcemia is associated with many diseases with primary hyperparathyroidism and some malignancies accounting for greater than...