Bacteriological Profile and Antimicrobial Susceptibility Pattern of Isolates from Patients with Septicaemia in Butembo, Democratic Republic of the Congo
Journal Title: Journal of Advances in Microbiology - Year 2017, Vol 6, Issue 4
Abstract
Background: Emergence of antimicrobial resistance has limited treatment options against bloodstream infections. This study aimed to determine bacterial isolates from blood culture of patients with bloodstream infection and their sensitivity to antimicrobials at patients attending the Central Laboratory of Research of the “Université Catholique du Graben” (UCG) in Butembo. Methodology: This was a cross-sectional study adopting a descriptive approach, conducted from January, 2015 to December, 2016. Blood was collected from a peripheral vein using an aseptic technique. The culture and the antimicrobial susceptibility testing were done by using standard methods according to the Clinical Laboratory Standard Institute guidelines. Results: The most isolated bacteria from blood culture of patient with bloodstream infections were Staphylococcus aureus (39.8%), Listeria spp. (17.4%), Moraxella spp. (14.3%), Bacillus spp. (13.4%) and Klebsiella rhinoscleromatis (4.1%). All bacterial isolates tested for sensitivity were resistant to the group of β-lactamine antibiotics except S. aureus which was sensitive only to vancomycin. It was also observed that all the bacterial species have a Multiple Antibiotic Resistance Index greater than 0.2. Conclusion: Bloodstream infections are life-threatening conditions, continuous and regular monitoring of antimicrobial susceptibility pattern of responsible bacteria is needed. From this study, we suggested gentamicin, doxycycline, ciprofloxacin, and levofloxacin as the first line antibiotics of choice for empiric treatment of bloodstream infections in Butembo.
Authors and Affiliations
Gabriel Kambale Bunduki, Zacharie Tsongo Kibendelwa, Adélard Kalima Nzanzu
Keywords
Related Articles
- EP ID EP338304
- DOI 10.9734/JAMB/2017/38055
- Views 92
- Downloads 0
Antibiotic Susceptibility and Plasmid Profile of Escherichia coli from Door Handles in Two Tertiary Institutions in Nasarawa State, Nigeria
Aim: This study is aimed at isolation, antibiotic susceptibility and plasmid study of Escherichia coli isolates from door handles in the study location. Study Design: Cross-sectional study. Place and Duration of Study: T...
RpoB Gene-Based Characterization of Non-Tuberculous Mycobacteria in Zimbabwe
Aims: To characterize archived nontuberculous Mycobacteria (NTM) samples previously isolated from humans across Zimbabwe during the 2014 national tuberculosis survey. The rpoB gene of the isolates was targeted for charac...
Effects of Processing Techniques on the Microbial Quality, Nutritional and Mineral Composition of Black-eyed Bean (Vigna unguiculata)
Introduction: Black eye pea (Vigna unguiculata), because of its preferred taste and nutritional value is one of the commonly eaten beans in Nigeria. Aim: The effect of processing techniques like soaking, dehulling and d...
Effects of Ampicillin on the Gut Microbiome of an Adult Male as Determined by 16S rRNA V4 Metagenomics Sequencing and Greengenes Bioinformatics Suite
Aims: To determine the effects of ampicillin on the relative abundance of the gut microbiota using Next Generation Sequencing (NGS) metagenomics platform and to predict metabolic functions with bioinformatics suite. Met...
Effects of Probiotics on Intestinal Microflora of HIV-infected Individuals
Aims: HIV-1 infection results in structural damage to the intestinal mucosa and changes of gut microflora following dysfunction of the gastrointestinal system, including compromised barrier function. Known properties of...