Bacteriological Profile of Neonatal Septicemia and Antibiogram of Isolates
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 2
Abstract
Background: Septicemia in neonates refers to generalized bacterial infection documented by positive blood culture in first four weeks of life. It is the leading cause of neonatal mortality and morbidity in India. Aim: To isolate and identify the bacteriologic etiologic agents responsible for neonatal sepsis and to determine the susceptibility pattern of isolates at Kurnool Medical College and Govt General Hospital, Kurnool. Materials and Methods: Two hundred and fifty two samples were collected from neonates for a period of ten months and processed in accordance with standard protocols. Antibiotic susceptibility of the isolates was done by Kirby-Bauer disc diffusion method as recommended in the National Committee for Clinical Laboratory Standards (NCCLS) guidelines. Results: Blood culture reports were positive in 54.7% cases. Among the culture positive cases, Gram positive isolates were 12.6% and Gram negative isolates were 42.1%. Staphylococcus aureus was the predominant Gram positive organism isolated and Klebsiella spp. was the predominant Gram negative organism isolated. Best overall sensitivity among Gram-negative isolates was to Imipenem (95.2%) followed by Tigecycline (92.8%).Gram positive isolates had sensitivity of 96.4% to Linezolid, 82% sensitivity to Vancomycin. Conclusion: Gram negative organisms are the leading cause of neonatal sepsis in this study and most of them are multi drug resistant. Therefore this study highlights the emergence of multi drug resistant strains at tertiary care centre.
Authors and Affiliations
Dr. J. Haritha, Dr. P. Hemasri, Dr. A. Renuka
Keywords
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- EP ID EP467820
- DOI 10.9790/0853-1802175254.
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