Bacteriological Profile of Neonatal Septicemia, Antibiogram and Correlation with CRP in A Tertiary Care Hospital
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 5
Abstract
Abstract: Neonatal septicaemia constitutes a significant cause of neonatal mortality in our country. Blood culture which is considered as gold standard for diagnosis is costly and time consuming. CRP is a rapid tool for screening of neonatal septicaemia and a reliable marker in the absence of positive blood cultures. In present study, we emphasize to study the correlation of C reactive protein with blood culture in neonatal septicemia as it is a relatively economical method and it accelerates the diagnostic process. In this prospective study done at Niloufer Hospital, Hyderabad, neonates admitted in NICU with clinical suspicion of sepsis were studied for 3 months from July 2017 to September 2017. Blood was collected from each patient aseptically and inoculated into Trypticase soy broth and subcultures were made on blood agar and Mac conkey agar, and antibiotic susceptibility test was done. Qualitative estimation of CRP was done by rapid CRP latex slide agglutination test. Of 126 neonates studied, 49 had only positive blood culture 13 had only positive CRP, while 52 had both positive CRP and blood culture. Both blood culture and CRP were negative in 12 neonates. The sensitivity, specificity, positive and negative predictive values of CRP were 80%, 19.67%, 51.48% and 48% respectively. CRP is a very good inflammatory marker and also highly sensitive in case of neonatal septicaemia. Blood culture reports are available only after 48-72 hours and so comparing CRP with blood culture reports provides a rapid and economical method to diagnose neonatal sepsis.
Authors and Affiliations
Dr. R. Vanishree, Dr. L. Prashanthi, Dr. Chandana Konda, Dr. P. Uma Devi
Keywords
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