BDDCS Applied to Over 900 Drugs
Journal Title: The AAPS Journal - Year 2011, Vol 13, Issue 4
Abstract
The online version of this article (doi:10.1208/s12248-011-9290-9) contains supplementary material, which is available to authorized users.
Authors and Affiliations
Leslie Z. Benet, Fabio Broccatelli, Tudor I. Oprea
Nicotine is a Selective Pharmacological Chaperone of Acetylcholine Receptor Number and Stoichiometry. Implications for Drug Discovery
The acronym SePhaChARNS, for “selective pharmacological chaperoning of acetylcholine receptor number and stoichiometry,” is introduced. We hypothesize that SePhaChARNS underlies classical observations tha...
Study of crystallization of endogenous surfactant in Eudragit NE30D-Free films and its influence on drug-release properties of controlled-release diphenhydramine HCI pellets coated with Eudragit NE30D
This study investigates the crystallization of the endogenous surfactant nonoxynol 100 in Eudragit NE30D-free films during storage and the influences of nonoxynol 100 on the dissolution of diphenhydramine hydrochloric ac...
A Kinetic Degradation Study of Curcumin in Its Free Form and Loaded in Polymeric Micelles
The online version of this article (doi:10.1208/s12248-015-9863-0) contains supplementary material, which is available to authorized users.
Anion-induced water flux as drug release mechanism through cationic Eudragit RS 30D film coatings
The objective of this study was to investigate the anion-controlled drug release mechanism through the cationic coating polymer Eudragit RS 30 D as a function of the anion attraction toward the polymer’s quartern...
Modeling, Simulation, and Translation Framework for the Preclinical Development of Monoclonal Antibodies
The industry-wide biopharmaceutical (i.e., biologic, biotherapeutic) pipeline has been growing at an astonishing rate over the last decade with the proportion of approved new biological entities to new chemical entities...