BEHAVIOURAL AND HISTOLOGICAL STUDY OF CRUDE EXTRACTS OF COSTUS AFER ON TEMPORAL LOBE OF WISTAR RATS
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2018, Vol 7, Issue 7
Abstract
Medicinal plants contain bioactive ingredients that can be used in the treatment of neurobehavioural disorder. In this study the neurobehavioural and histological effect of ethanolic extract of Costus Afer was studied. The study lasted for 14 days involving 29 adult Wistar rats, nine (9) rats were used for oral toxicity test, while 20 rats were divided into four groups of five rats each, A, B, C, D. Group A served as the negative control and received 1m of distilled water, B and C served as experimental group and received 100mg/kg body weight and 150mg/kg body weight respectively, while D served as positive control and received 2.5mg/kg of diazepam. On the fourteenth day neurobehavioural test was carried out using elevated plus maze and the animals sacrificed and the brain harvested. In the elevated plus maze the animals spent more time in the closed arm and closed arm entries increased when compared to the positive control while Head dip, grooming and rearing decreased. The extract showed an anxiogenic effect in this study. The extract distorted the histology of the temporal lobe. The distortion increased with increase in dosage. In conclusion, the result of this study showed that ethanolic extract of Costus Afer lack anxiolytic effect and altered the normal histology of the temporal lobe.
Authors and Affiliations
Okoronkwo, Samuel Okafor
Keywords
Related Articles
- EP ID EP627472
- DOI -
- Views 123
- Downloads 0
MODERN TOOLS IN FORENSIC DENTISTRY- A REVIEW OF ITS LITERATURE.
As we enter a new millennium, society is faced with fresh challenges in every conceivable area. Despite leaps in modern technology, medical breakthroughs and the geographical changes that the last century has brought, cr...
MEDICAL PRESCRIPTION: ERRORS DETECTED IN NATIONAL HEALTH INSURANCE CENTRAL HOSPITAL OF ASUNCIÓN PARAGUAY
This paper aims to describe errors in medical prescriptions (EMP) issued by various medical professionals and the interventions in the Pharmacy of the Central Hospital of the Social Security Institute (HC-IPS) of Paragua...
CHANGING THE LIPID PROFILE AND RENAL FUNCTIONS BY ALLIUM SATIVUM, NIGELLA SATIVA AND HIBISCUS SABDARIFFA IN ESSENTIAL HYPERTENSIVE PATIENTS
Background: Essential hypertension is a global major health problem affecting more than a billion individual. The aim of the present study is to find out a new effective agent with high safety and low cost by examining A...
ANALYSIS OF THE EFFECT OF LEVODOPA ON NEUROTRANSMITTERS USING QUANTITY METHOD
The Benefit of the Levodopa or L-Dopa (LEV) to reduce the symptoms of Parkinson’s disease and have been studied and presented a concern for promoting the acceleration of neurodegeneration. The objective of the study is t...
HOW FAMILY HISTORY OF THE DISEASE AFFECTS KAP REGARDING BREAST CANCER AND ITS SCREENING METHODS
Pakistan has one of the highest incidence rates of breast cancer in Asia. Breast cancer is a major contributor towards cancer related mortality and morbidity in Pakistani women. The study aimed to examine the effects of...