Bench to Bedside: Future Therapies For Treatment Of Anemia In Patients With Chronic Kidney Disease
Journal Title: BMH Medical Journal - Year 2017, Vol 4, Issue 4
Abstract
The link between chronic kidney disease (CKD) and anemia has been known for over 180 years ever since it was highlighted by the legendary Richard Bright. The key etiological factors responsible for anemia due to renal disease were identified in the 1950s as relative deficiency of erythropoietin and reduced red cell survival as well as abnormalities in iron metabolism. This knowledge was not translated to therapeutics for the next three decades and red cell transfusions were the main-stay of treatment of renal anemia till recombinant human erythropoietin (rHuEPO) was introduced in the 1980s [3]. Recurrent transfusions, in addition to causing HLA sensitization, frequently resulted in iron overload with subsequent parenchymal iron deposition and organ dysfunction - a well-known scenario in the pre-erythropoetin era and use of iron chelation therapy was a feasible therapeutic option in long-term dialysis patients.
Authors and Affiliations
KM Murali
Keywords
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