Bendamustine for Relapsed and Refractory Hodgkin Lymphomas: Four Cases and a Review of the Literature
Journal Title: International Blood Research & Reviews - Year 2014, Vol 2, Issue 4
Abstract
Aims: The management of relapsed/refractory Hodgkin lymphoma is challenging and new choices are needed. Brentuximab vedotin and bendamustine are two effective drugs in these cases. The aim of this study is to present the response to bendamustine after brentuximab failure. Study Design: Retrospective study evaluating the response to bendamustine in four cases with relapsed or refractory Hodgkin lymphoma. Place and Duration of Study: Cukurova University Faculty of Medicine Department of Oncology, between 2012 and 2014. Methodology: Clinical and metabolic responses to bendamustine in four cases with relapsed refractory Hodgkin lymphoma were evaluated. Informed consent was obtained from the patients. Bendamustine was used in four cases with very refractory Hodgkin lymphoma after Brentuximab failure. The dosage was 120 mg/M2 for two consecutive days in 4 weeks, without growth factor support. Results: Four cases with relapsed or refractory Hodgkin lymphoma were treated with bendamustine after brentuximab vedotin failure. Complete metabolic response was documented in two cases,one case did not respond and only short duration of response was determined in one case. Conclusion: Bendamustine is an effective and cost-effective choice in cases with relapsed/refractory Hodgkin lymphoma after brentuximab vedotin failure. However response is of short duration and definitive treatment must be performed as soon as possible.
Authors and Affiliations
Semra Paydas
Keywords
Related Articles
- EP ID EP242534
- DOI 10.9734/IBRR/2014/8834
- Views 100
- Downloads 0
Effect of HIV Infection and Antiretroviral Therapy Duration on Reticulocyte Count and Red Cell Indices
Aim: To determine the Red cell indices and Reticulocyte count values in HIV-positive patients under antiretroviral treatment and those not under antiretroviral treatments with varying durations of HIV infection and antir...
Molecular Detection of Hepatitis B Viruses (HBV)
Aims: HBV causes both acute and chronic infections and is transmitted through blood or other body fluids. The present study deals with the molecular detection of HBV using PCR. Study Design: Confirmed positive samples...
Anti-retroviral Treatment Related Haematological Disorders among HIV- Infected Children Attending HIV Clinic at Yekatit 12 Hospital, Addis Ababa, Ethiopia
Background: The Management of drug toxicities is increasingly becoming a crucial component of human immunodeficiency virus infection and improvement of antiretroviral therapy in developing countries like Ethiopia. The se...
Bendamustine for Relapsed and Refractory Hodgkin Lymphomas: Four Cases and a Review of the Literature
Aims: The management of relapsed/refractory Hodgkin lymphoma is challenging and new choices are needed. Brentuximab vedotin and bendamustine are two effective drugs in these cases. The aim of this study is to present the...
Effect of Momordica charantia (Bitter Melon) Leaves on Haemoglobin Concentration in Male Albino Rats
This research work was carried out to investigate the effect of the aqueous extract of Momordica charantia on haemoglobin concentration in albino rats. The aqueous extract of Momordica charantia was prepared from the lea...