Bendamustine for Relapsed and Refractory Hodgkin Lymphomas: Four Cases and a Review of the Literature
Journal Title: International Blood Research & Reviews - Year 2014, Vol 2, Issue 4
Abstract
Aims: The management of relapsed/refractory Hodgkin lymphoma is challenging and new choices are needed. Brentuximab vedotin and bendamustine are two effective drugs in these cases. The aim of this study is to present the response to bendamustine after brentuximab failure. Study Design: Retrospective study evaluating the response to bendamustine in four cases with relapsed or refractory Hodgkin lymphoma. Place and Duration of Study: Cukurova University Faculty of Medicine Department of Oncology, between 2012 and 2014. Methodology: Clinical and metabolic responses to bendamustine in four cases with relapsed refractory Hodgkin lymphoma were evaluated. Informed consent was obtained from the patients. Bendamustine was used in four cases with very refractory Hodgkin lymphoma after Brentuximab failure. The dosage was 120 mg/M2 for two consecutive days in 4 weeks, without growth factor support. Results: Four cases with relapsed or refractory Hodgkin lymphoma were treated with bendamustine after brentuximab vedotin failure. Complete metabolic response was documented in two cases,one case did not respond and only short duration of response was determined in one case. Conclusion: Bendamustine is an effective and cost-effective choice in cases with relapsed/refractory Hodgkin lymphoma after brentuximab vedotin failure. However response is of short duration and definitive treatment must be performed as soon as possible.
Authors and Affiliations
Semra Paydas
Erythropoietic and Bone Marrow Stimulating Activity of Terminalia catappa Extract: Possible Role of Nitric Oxide Signaling
Aims: We assessed the capacity and mechanism of Terminalia catappa (TC) to induce erythropoiesis in vivo in phenylhydrazine- induced anemic mice. Place and Duration of Study: Sample: This study was carried out at Departm...
Assessment of CD4 Count and Some Haematological Parameters of HIV Positive Patients Co-infected with Hepatitis B Virus in Osun State, Nigeria
Background: Increased morbidity and mortality rates have been reported among patients co-infected with Human Immunodeficiency Virus (HIV) and Hepatitis B Virus (HBV). Aims: To determine the prevalence of HBV infection am...
Atrial Function and Glutathione in Children with Iron Deficiency Anemia- Tanta-Egypt-2012
Aims: is to correlate the atrial function with the level of oxidative stress marker (Glutathione) in children with Iron deficiency anemia (IDA). Materials and Methods: Thirty children with IDA and 20 healthy children ha...
Prevalence of Plasmodium and Salmonella Infections among Pregnant Women with Fever, Presented to Three Hospitals in Ogun and Lagos State, South-West Nigeria
Aims: The study was undertaken to establish prevalence of plasmodium and salmonella infections among pregnant women manifesting fever, presented to three hospitals in Lagos and Ogun state, Nigeria. To determine the rate...
Iron Status and Red Cell Parameters in Pregnant and Non-pregnant Adolescents in Côte d’Ivoire (West Africa)
Aims: The objective of this study was to evaluate iron metabolism and compare iron stores between pregnant and non-pregnant adolescents in Côte d’Ivoire. Place and Duration of Study: The study was undertaken with 187 vo...