Beneficial impacts of choline in animal and human with special reference to its role against fatty liver syndrome
Journal Title: Journal of Experimental Biology and Agricultural Sciences - Year 2017, Vol 5, Issue 0
Abstract
Choline exists in feed ingredients and also synthesized in the body. It is essential for the physiological functions such as performance and lowering liver and body fat. If choline is insufficient in the diet, the liver fat content and abdominal fat content increase causing a metabolic disorder known as a fatty liver syndrome. Thus, dietary supplementation of choline as synthetic choline chloride or through natural herbs to the diets is compulsory. Besides fatty liver syndrome, choline deficiency causes loss of hepatocytes, heart diseases, bone and growth development abnormalities and impairment in kidney functions. The main indication of choline deficiency is raised up the level of liver enzymes like alanine transaminase (ALT). This ALT is usually measured clinically during diagnostic evaluation of hepatocellular injury to fix liver health. Lipotropic nutrients like choline could prevent fatty liver disorders through several mechanisms, such as increased hepatic very low-density lipoproteins (VLDL) secretion. Human and animal studies have reported protective impacts of choline for fatty liver disease (FLD) in addition to coronary heart disease (CVD) prevention from epidemiological data. Nowadays, choline supplementation is below the dietary recommendations because of a lack of understanding the importance of this vital nutrient for human and animal health. In the current review article, literature showed that choline can be considered as a powerful lipotropic agent that should be used as commercial feedadditive to cope the metabolic disorder like fatty liver syndrome in poultry, exclusively in layers reared in cages and thus replaced synthetic medicine that being used against fatty liver syndrome.
Authors and Affiliations
Muhammad Saeed, Mahmoud Alagawany, Muhammad Asif Arain, Mohamed E. Abd El-Hack, Kuldeep Dhama
Keywords
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- EP ID EP428126
- DOI 10.18006/2017.5(5).589.598
- Views 67
- Downloads 0
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