Benefits and side effects of cyclosporine a 0.05% eye drops in dry eye diseases
Journal Title: Tropical Journal of Ophthalmology and Otolaryngology - Year 2017, Vol 2, Issue 1
Abstract
Objectives- To know the effect of topical cyclosporine A 0.05% eye drops in dry eye disease and evaluate its side effects. Materials and methods- 30 cases, above age of15 year, of dry eye syndrome were included. Grading were doneas following eight symptoms, chronic sandy-gritty irritation, persistent dryness, foreign body sensation, scratching and burning, watery eyes, photophobia, itching and transient blurring of vision. The signs noted in cases of dry eye are tear breakup time and schirmer value. Cyclosporine A 0.05% ophthalmic emulsioneye drop used 12 hourly. Follow up of patients on after 15 days, every month for 3 months then after 6 months. Results- In 30 cases, malefemale ratio were 5:1. According tosymptoms, 50% mild, 30% moderate and 20% were severe, andaccording to signs 46.66%mild,33.33% moderate, and 20.00% were severe. After cyclosporine a treatment 20 became normal, 8 partially improved and 2 no improvement in symptoms while 20 became normal, 9 partially improved and1patient showed no improvement in signs. Local side effect likeburningin 23.33%, discharge in 60.66%, foreign body sensation in 13.33%, stinging in 13.33%, conjuctival hyperemia in 20% and visual disturbance in 6% eyes. Conclusions- Topical cyclosporine A 0.05% eye drop twice daily in dry eye diseases improve symptom as well as signs (schirmer”s value and tear breakup time) with minimal tolerable local side effects.
Authors and Affiliations
Mamta Hara, Hemendra Parashar
Keywords
Related Articles
- EP ID EP396369
- DOI 10.17511/jooo.2017.i1.04.
- Views 239
- Downloads 0
Refractory errors in medical students in a teaching hospital in rural Telangana
Introduction: Refractive errors are attributing to major public health problem. The increasing prevalence rates of myopia have reached to epidemic proportions in many Asian countries. Thisstudy was done to determine the...
A study of assess the prevalence of dry eye and its associated risk factors in a tertiary care hospital
Introduction: Dry eye is a major tear deficiency disorder which affects millions of people worldwide. Dry eye refers to disorders of the tear film due to reduced tear production and/or excessive tear evaporation associat...
Interlay myringoplasty: hearing gain and outcomein large central tympanic membrane perforation
Background: Tympanic membrane Perforations primarily results from middle ear infections and myringoplasty is a surgical procedure used to repair the tympanic membrane and to improve hearing. The interlay technique is a n...
To study the effect of Rebamipide 2% ophthalmic suspension in Dryeye
Purpose: Current available therapies such as lubricants and anti-inflammatory drugs alleviate symptoms and reduce signs of dry eye. Various drugs have been developed to treat the underlying cause of disease .One such dru...
Childhood Blindness: Causes & Prevention
The global prevalence of childhood blindness is approximately 1.4 million. Nearly 500,000 children become blind every year - nearly one per minute.Worldwide, vitamin A deficiency is the commonest single cause of childhoo...