BENEFITS VERSUS RISKS OF PROTON PUMP INHIBITORS: ARE WE OPENING THE CAN OF WORMS
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2015, Vol 5, Issue 1
Abstract
Proton pump inhibitors (PPIs) are one of the most commonly used drugs worldwide They are indicated for treatment of Gastro-esophageal Reflux Disease (GERD), acid peptic disorders, stress ulcers and prophylaxis of NSAID induced ulcers.[1] PPIs are more efficacious than other drugs like histamine -2 receptor blockers for the treatment of these disorders.[1] Though PPIs are highly potent and effective acid suppressors they are often misused and prescribed irrationally. The incidence of irrational use of PPIs varies from 40-70 % in different studies. [2] In one of our previous studies 58 % of PPIs prescriptions were irrational. [2] These findings become much more significant in the light of recent findings which suggest correlation of long term use of PPIs to myocardial infarction and kidney injury. [3,4] The PPIs may be deemed safe for short term use but chronic use carries risk of hip fractures, infection with clostridium difficle, community acquired pneumonia.[2] PPIs exposure in elderly population was also found to be associated with hyperparathyroidism in one recently conducted study.[5] The ongoing long term studies for assessing the safety and association of PPIs with various serious outcomes may open up a new can of worms. Keeping in mind the benefits as well as risks of proton pump inhibitors, clinicians should judiciously use these drugs in practice. The patients should also be educated regarding the adverse outcomes of PPIs on long term therapy as these drugs are easily available without prescription.
Authors and Affiliations
Naser Ashraf Tadvi| Assistant Professor, Department of Pharmacology, College of Medicine, Majmaah University, Email id: nasertadvi@yahoo.co.uk, Sajid Hussain| Assistant Professor, Department of Pharmacology, College of Medicine, Majmaah University, Usama Bin Ghaffar| Assistant Professor, Department of Pathology, College of Medicine, Majmaah University
Keywords
Related Articles
- EP ID EP11571
- DOI 10.5958/2319-5886.2016.00018.7
- Views 266
- Downloads 10
Study on the effect of exclusive breastfeeding education on breastfeeding self-efficacy in mothers referring to affiliated hospitals of Medical Sciences Universities in Tehran during 2010-2011
Breastfeeding saves the lives of more than half a million infants in a year and cause strong emotional relationship between mother and child and their psychosocial development of personality. The aim of this study is t...
SALIVARY DUCT CARCINOMA OF PAROTID GLAND- AN INCIDENTAL FINDING
Salivary duct carcinoma, a recently added separate entity of salivary gland tumor is a rare tumour with its aggressive behaviour. Due to morphological similarities with ductal carcinoma of breast the name salivary duct...
AN UNUSUAL FINDING OF EPIDIDYMAL SPERM GRANULOMA IN AN ORCHIDECTOMY SPECIMEN: A CASE REPORT
Epididymal sperm granuloma as a cause of granulomatous epididymitis is rare. Most of the cases are found post vasectomy as part of the late vasectomy syndrome. These lesions are known to mimic other conditions includin...
The Effect of Hemodialysis on Hemoglobin Concentration, Platelets count and White Blood Cells Count in End Stage Renal Failure
To evaluate the effect of hemodialysis machine in complete blood count with focus on hemoglobin, platelets and total white blood cells count for patients of end stage renal disease, to evaluate the effect of dialysis on...
Analysis of the effects of a support program based on psychosocial needs of families on care burdens of family caregivers of patients with ischemic heart disease hospitalized in Chamran heart ward of Isfahan University of Medical Sciences
This study was conducted in 2015 with goal of analysis of the effects of a support program based on psychosocial needs of families on care burdens of family caregivers of patients with ischemic heart disease hospitalize...