Benidipine Reduces Ischemia/Reperfusion Injury Following Testicular Torsion/Detorsion in Rats
Journal Title: Iranian Journal of Veterinary Surgery - Year 2017, Vol 12, Issue 2
Abstract
Objective-This study aimed to determine the protective effects of benidipine on testicular injury after testis torsion/detorsion in ratsDesign-Experimental study Animals-Fifteen male Sprague-Dawly rats weighing 200-220g Procedure-Rats were randomly divided into 3 groups: sham (healthy group with sham operation, n=5), IRC group (control group in which I/R injury was performed by torsion the right testis 720 º clockwise for 2 hours and detorsion for 2 hours, n=5), and IRB group (IR + benidipine, I/R process was performed following orally benidipine administration + 4 mg/kg benidipine, n=5). Levels of glutathione peroxidase (GPx) and malondialdehyde (MDA) were determined in testicular tissues of rats. Testicular tissues were also examined histopathologically. Results-The levels of MDA (P<0.0001) was significantly increased augmented in the testis of IRC group rat. Testicular GPx levels were significantly reduced (p<0.0001) after I/R. Administration of benidipine before torsion prevented the increase in lipid peroxidation and alleviated GPx levels. Benidipine also impeded ischemia/reperfusion cellular damage and histological alternations in testicular tissue Conclusion and clinical relevance-These results show that therapy with benidipine before torsion may induce protective effects against ischemia/reperfusion injury
Authors and Affiliations
Sara Javanmardi, Monireh Khordadmehr
Keywords
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- EP ID EP633132
- DOI 10.22034/ivsa.2017.97394.1128
- Views 166
- Downloads 0
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Benidipine Reduces Ischemia/Reperfusion Injury Following Testicular Torsion/Detorsion in Rats
Objective-This study aimed to determine the protective effects of benidipine on testicular injury after testis torsion/detorsion in ratsDesign-Experimental study Animals-Fifteen male Sprague-Dawly rats weighing 200-220g...