Benign endometrial lesions in premenopausal women: three-dimensional power Doppler sonography and cytokines content
Journal Title: Progress in Health Sciences - Year 2013, Vol 3, Issue 2
Abstract
Purpose: To investigate the IL-2, IL-4, IL-6, IL-8, IL-10, TNF-a, IL-1β, IFN-γ at the local and system levels in endometrial polyps and hyperplasia in premenopausal women; to assess whether three-dimensional power Doppler indices can discriminate between hyperplasia and proliferative endometrium. Materials and methods: The prospective analysis included 80 premenopausal women with the suspicion of endometrial hyperplasia and endometrial polyp according to 2D ultrasonography data. Three groups of patients were analyzed according to histological data. There were 25 women with simple endometrial hyperplasia without atypia (the first study group), 15 patients with hyperplastic endometrial polyps (the second study group) and 40 healthy women with endometrium in the early proliferative phase (control group) in premenopausal age. The levels of some cytokines were determined by enzyme linked to immunosorbent assay in serum and in aspirates from the uterus cavity. Three-dimensional power Doppler indexes of the uterus and endometrium were measured in endometrial hyperplasia and proliferative endometrium. Results: Significant dysfunctional changes of local immune system of uterine mucosa in endometrial hyperplasia and endometrial polyp are expressed in activation of pro-inflammatory cytokines, with a deficit of anti-inflammatory cytokines. Endometrial three-dimensional power Doppler indices of uterine and endometrium were significantly higher in endometrial hyperplasia. Conclusions: The local secretion imbalance of pro- and anti-inflammatory cytokines is present in endometrial hyperplasia and polyps in premenopausal age. Endometrial perfusion increases in endometrial hyperplasia by using three-dimensional power Doppler sonography in comparison with healthy women.
Authors and Affiliations
OV Lysenko
Keywords
Related Articles
- EP ID EP75335
- DOI -
- Views 93
- Downloads 0
A professional profile of the contemporary teacher in the opinion of nursing and midwifery students
Introduction: The transformation of the system of nurse and midwife training is becoming the object of empirical research concerning the effectiveness of the teaching/learning process. Purpose: To know the expectations...
Selected nutritional behaviors in children and youth at school age – preliminary study
Purpose: To evaluate diet, frequency and type of products consumed and offered at school shops. Materials and methods: Studies were conducted in 2014 among 159 pupils of three randomly selected schools in Bialystok (elem...
The incidence of vasospasm after intracerebral haemorrhage
Purpose: Cerebral vasospasm occurs frequently after aneurismal subarachnoid haemorrhage (SAH) and is a dangerous complication. Only a few cases of cerebral vasospasm after intracerebral haemorrhage (ICH) have been report...
Dental caries profile among 6-8-year old children from Bialystok District, Poland
Purpose: The purpose of this study was to evaluate the status of permanent teeth in children aged 6-8 years from the Bialystok District, Poland. Material/Methods: 542 children aged between 6 and 8 years from Bialystok a...
Drug use, smoking, alcohol abuse and assertiveness of medical students from Poland and Belarus
Introduction: Human health is largely determined by factors such as human behavior and style of life. Purpose: To evaluate selected patterns of behavior of medical students, such as smoking, alcohol abuse, drug use, and...