BERYLLIUM DRIVEN HEMATOLOGICAL AND SEROLOGICAL ALTERATION; THAT CURED BY CHELATION VIA NARINGENIN IN ALBINO RATS
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 9
Abstract
Objective: Environment faces range of pollutions threats due to extensive industrialization and deforestation. In exists scenario metal contamination deadly one among them. Beryllium is 44th most abundant element in earth crust which executes their discharge in society through fossils fuel combustion besides daily routines things as in chips of electric gadgets jewelry, dental crown. The objective of the present investigation was the reduction of beryllium harmful effect through naringenin in female albino rats. Methods: Female rats were administered by 1mg/kg dose intraperitoneally daily for 28 days alone as well as before/along with three doses (12.5, 25, and 50 mg/kg) of naringenin orally (7 days once in day). Hematological and serological analysis was performed for this clinical research. Results: Beryllium exposure caused severe alteration in hematological markers evident by a significant diminishment of hemoglobin, red blood corpuscles, mean corpuscular hemoglobin concentration and hematocrit and promoted the level of white blood corpuscles and platelets. Similarly, serological parameters; triglycerides cholesterol and glucose were altered significantly as the response of lipid bilayer peroxidation. All these variables were retrieval near to control ardently by three doses of naringenin. Conclusion: In short naringenin might be useful as in natural chelation for beryllium body burden.
Authors and Affiliations
ANJANI VERMA , SAMRAT RAKSHIT , SATYENDRA KUMAR NIRALA , MONIKA BHADAURIA
Keywords
Related Articles
- EP ID EP646627
- DOI -
- Views 116
- Downloads 0
PACKAGING OF HEPATITIS B SURFACE ANTIGEN VACCINE AND MORINGA OLEIFERA EXTRACT INTO CHITOSAN NANOPARTICLES
Objective: Oftentimes, the recombinant antigen for the use of vaccines is less immunogenic than live attenuated or inactive vaccines. Hence, a potent adjuvant is needed to enhance the immune response. Moreover, the role...
PHYSICAL AND CHEMICAL CHARACTERIZATION OF GREEN SYNTHESIZED SILVER NANOPARTICLES USING STEM OF HIBISCUS VITIFOLIUS L. AND ITS ANTIMICROBIAL AND ANTIOXIDANT POTENTIAL
Objectives: The aim of our work was to synthesize the silver nanoparticle (AgNP) using Hibiscus vitifolius L. stem extract its characterization and evaluation of antimicrobial and antioxidant assay. Materials and Method...
AN OVERVIEW ON DRUG-INDUCED HEPATOTOXICITY
Liver is a vital organ, contributing in most of the metabolic and physiological processes of our body. It plays principal role in detoxification of various drugs and xenobiotics. Though liver possess tremendous regenerat...
KNOWLEDGE AND PERCEPTIONS OF SELF-MEDICATION PRACTICES IN AN URBAN COMMUNITY
Objective: This study was conducted with the aim to assess the knowledge and attitude of self-medication practices among the residents of an urban community. Methods: A cross-sectional, observational study was conducted...
EVALUATION AND COMPARISON OF CYTOTOXIC EFFECT OF VILAZODONE HYDROCHLORIDE WITH 5-FLUOROURACIL IN HT-29 BOWEL CANCER CELL LINE
Objectives: Vilazodone hydrochloride is a novel selective serotonin reuptake inhibitor (SSRI) used to treat major depressive disorders. There are only sparse data available to know about the SSRI’s and its association wi...