Beta 2 Microglobulin (B2M) As a Marker of Disease Severity and Progression in Acute Myeloid Leukemia (AML)
Journal Title: Scholars Academic Journal of Biosciences - Year 2016, Vol 4, Issue 7
Abstract
Abstract:B2M, a known prognostic factor in multiple myeloma and reflects tumor burden and turnover. Few clinical studies have shown B2M to have prognostic relevance in AML. The study was planned to evaluate the status of B2M in patients of AML before and after chemotherapy.30 newly diagnosed cases of AML & 30 age and sex matched healthy controls were taken. AML patients were treated with combination chemotherapy of cytarabine and an anthracycline. Routine biochemistry, complete hemogram, serum B2M were performed in newly diagnosed patients before treatment and in controls. The investigations were repeated at first complete remission or after 4 weeks of chemotherapy (whichever is earlier). B2M were measured by ELISA.60% patients achieved remission, 26.7% did not achieve remission and 13.3% expired. Baseline B2M levels were significantly raised in AML patients (B2M:1.76±0.95µg/mL vs0.99±0.67µg/mL, p=0.004). B2M levels at diagnosis were significantly higher in patients who expired than patients who achieved remission (p=0.034). B2M levels were significantly correlated with known prognostic factors; total leucocyte count and blast count in peripheral blood (p=0.001 & 0.001).B2M levels decreased significantly after chemotherapy only in remission group (p=0.015).Serum B2M levels have prognostic value in AML patients. Studies are required in larger number of patients. Keywords:B2M, AML, blast count in peripheral blood
Authors and Affiliations
Dokwal S, Ghalaut VS, Lokanathan V, Bansal P, Sarkar M, Gupta G
Keywords
Related Articles
- EP ID EP372441
- DOI -
- Views 91
- Downloads 0
The basic evaluation of production process of potable water from waste water by solar energy
Sweet water scarcity is human future wonder since usual technologies used to produce water from salty water are expensive (Reverse osmosis, Electro dialysis) or depends on fossil energies (Multi stage flash, multi effect...
Lipid derangement and cardiovascular risk in female patients with major depressive disorder
Lipid disorder is well recognized risk factor for cardiovascular disease. The association of lipid derangement with depressive disorder has been a recent focus of research specially in female. The objective of this study...
Histopathological study of Perimenopausal Abnormal Uterine Bleeding
Abstract: Abnormal Uterine Bleeding (AUB) is defined as any bleeding that does not correspond with the frequency, duration or amount of blood flow of a normal menstrual cycle. Endometrial assessment by endometrial biopsy...
Accumulation of Fluoride from Natural Water Sources in Oreochromis mossambicus (Peters, 1852)
O. mossambicus (Tilapia) samples from five study sites Ernakulam, Alappuzha town, Mannancherry, Ambalappuzha and Kuttanad were analyzed for the fluoride content. The water from which the fishes were collected was also an...
Phylogenetic analysis of five populations of rice eel in south china based on mtDNA D-loops
Abstract: Phylogenetic inference was conducted to analyze genetic variation of five Monopterus albus populations from south China based on mitochondrial control region of 501 bp in length. Totally 69 individuals were exa...