Beta Cell Dysfunction, Insulin Resistance and Impaired Insulin Sensitivity in Obese Adolescents
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 10
Abstract
Introduction: Changes in food consumption and health habits that have developed over the last three decades, the prevalence of obesity in children and adolescents has increased in both developed and developing countries. This has led to a striking worldwide increase in the rate of type 2 diabetes mellitus in the adolescent age group. Materials and Methods: In the present study, a total of sixty seven subjects were studied comprising of 36 obese adolescents (15 males, 21 females) and 31 (16 males, 15 females) apparently healthy normal weight adolescents of age group between 17-19 years. In all the subjects BMI, waist circumference, hip circumference was measured, GTT was done, and the serum concentrations of fasting glucose, 2 hr glucose and fasting insulin were estimated. Further HOMA-IR, GF/IF, QUICKI, HOMA%B were calculated. Results: Increased insulin concentrations was observed in obese individuals (18.18±1.29) when compared to non obese individuals (9.41±3.19). Significantly higher HOMA-IR (3.97±2.61 vs 1.97±0.69) (p<0.001) and HOMA%B (269.32±147.02 vs 173.07±92.94) (P<0.01) were observed in obese individuals when compared to non obese individuals. GF/IF (6.31±3.25 vs 10.26±4.18) (p<0.001) and QUICKI (0.32±0.02 vs 0.35±0.02) (p<0.001) were significantly lower in cases when compared to controls. BMI was positively correlated with insulin resistance (r= 0.536, p<0.001) and negatively correlated with insulin sensitivity (r=-0.545, p<0.001) and both were found to be statistically significant. The odds of developing insulin resistance and impaired insulin sensitivity is 6.86 and 5.33 times respectively more in obese when compared to non obese individuals. Conclusion: The results demonstrate that both insulin resistance and insulin sensitivity predict conversion to diabetes in obese adolescents. Improving insulin resistance may be crucial for the prevention of both type 2 diabetes and premature cardiovascular diseases in this young population at risk. Lifestyle measures have to be taken to improve IR.
Authors and Affiliations
Dakshayani Patlolla
Keywords
Related Articles
- EP ID EP528699
- DOI -
- Views 66
- Downloads 0
Prospective Study of Burn Wound for Microbial Involvement and Antimicrobial Susceptibility from a Tertiary Center of Gwalior
Background: The major challenge for a burn team is nosocomial infection in burn patients, which is known to cause over 50% of burn deaths. Aims and Objectives: To assess the pattern of bacterial colonization in a burn wo...
A Study on Carcinoma Penis
Carcinoma penis is quite common in our country .Though in decreasing trends, its racial, cultural, socioeconomic factors plays role in its etiology. The aims of my study are To find out the incidence of cancer penis amon...
Role and Prevention of Tobacco for Oral Health Care. Where Are We Now???
Tobacco use in India continues to promote various diseases and kill several individual but still no significant steps are been taken to get rid of this threat. Not only cancer but tobacco plays as the key factor for vari...
Vitamin B12 Deficiency in Metformin Treated type 2 Diabetic Patients and Factors Associated with it: A Cross-Sectional Study
Objectives: The objectives of the present study were to assess frequency of vitamin B12 deficiency in metformin treated diabetic patients and to evaluate various factors associated with B12 deficiency. Materials and Meth...
A Comparative Study of Laparoscopic versus open Appendicectomy in a District Hospital Setup
Introduction: Laparoscopic appendectomy and open appendectomy are the two methods of choice for appendectomy, the acceptance of laparoscopy over laparotomy still remaining a dogma. The specific aim was to compare the out...