Bgl II Polymorhism of the α2β1 Integrin Gene in Macedonian Population
Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2010, Vol 3, Issue 2
Abstract
Background. Glycoprotein (GP) Ia/IIa or α2β1 integrin is a platelet receptor for collagen and it mediates platelet adhesion to vascular subendothelium and is involved in thromb formation. Genetic polymorphism of α2β1 known as Bgl II affects the density of platelet GP Ia/IIa receptor on the platelet surface. Recent studies had shown relationship between this polymorphism and the risk of myocardial infarction, stroke, as well as diabetic retinopathy. Aim. The aim of this study was to determine the frequency of this polymorphism in Macedonian healthy population. Materials and Methods. We genotyped 217 healthy Macedonian individuals using the PCR and RFLP (restriction fragment length polymorphism) method. Results. The allele frequencies in this study were 0.32 for Bgl II (+) allele and 0.67 for Bgl II (-). Distribution of Bgl II genotypes in Macedonian population was Bgl II (+/+) = 16/217 (7.3%), Bgl II (+/ -) =107/217 (49.3%) and Bgl II (-/-) = 94/217 (43.3%). Conclusion. Our results showed a slightly lower proportion of the Bgl II (+) allele (0.32) in Macedonian population, but not significantly different from other Caucasian population.
Authors and Affiliations
Marica Pavkovic| Department of Hematology, Faculty of Medicine, University “Ss Kiril and Metodij”, Skopje, Republic of Macedonia, Aleksandar Petlichkovski| Institute for Immunobiology and Human Genetics, Faculty of Medicine, University “Ss Kiril and Metodij”, Skopje, Republic of Macedonia, Aleksandar Stojanovic| Department of Hematology, Faculty of Medicine, University “Ss Kiril and Metodij”, Skopje, Republic of Macedonia, Dejan Trajkov| Institute for Immunobiology and Human Genetics, Faculty of Medicine, University “Ss Kiril and Metodij”, Skopje, Republic of Macedonia, Mirko Spiroski| Institute for Immunobiology and Human Genetics, Faculty of Medicine, University “Ss Kiril and Metodij”, Skopje, Republic of Macedonia
Keywords
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- EP ID EP8735
- DOI 10.3889/MJMS.1857-5773.2010.0096
- Views 338
- Downloads 19
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