Biochemical Changes Induced by the Toxicity of Variable Sizes of Silver Nanoparticles
Journal Title: Journal of Pharmaceutical Research International - Year 2014, Vol 4, Issue 24
Abstract
Background: Silver nanoparticles (SNPs) rapid involvement in industry and nanomedicine increased human exposure to variable forms of these particles, with possible potential risk on human health. Aims: The aim of this study is to investigate the biochemical changes induced by variable sizes of SNPs toxicity. Place and Duration of Study: Faculty of Medicine, The University of Jordan and the College of Applied Medical Sciences at Aljouf University, Saudi Arabia, between January 2013 and January 2014. Study Design: Forty-two male mice were subjected to a daily single dose (1mg/kg body weight) of SNPs using five different sizes (10 nm, 20 nm, 40 nm, 60 nm and 100 nm) for 35 days. Methodology: Biochemical changes of the following eleven biochemical tests were determined: aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, triglycerides, total bilirubin, creatinine, total protein, albumin, urea, uric acid and total cholesterol. Results: Silver nanoparticles significantly elevated aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, triglycerides, total bilirubin and creatinine, with no significant change in total protein level while albumin and total cholesterol levels were lowered. Conclusion: The findings indicate that exposure to SNPs produced significant biochemical changes that might affect the functions of the vital organs. Moreover, these alterations were size-dependent with smaller particles (10 nm and 20 nm) induced more alterations than the larger ones.
Authors and Affiliations
Qais Jarrar, Abdelkader Battah, Fatima Obeidat, Khairat Battah
Keywords
Related Articles
- EP ID EP344533
- DOI 10.9734/BJPR/2014/14666
- Views 79
- Downloads 0
Synergistic Antibacterial Activity of Pleurotus Species (Mushroom) and Psychotria microphylla (Herb) against Some Clinical Isolates
Aims: This study investigated the synergistic antimicrobial activity of the extracts of Pleurotus species and Psychotria microphylla against five clinical bacterial isolates: Escherichia coli, Pseudomonas aeruginosa, Sal...
The Comparative Effect of Medicinal Herb Feverfew with that of a Synthetic Parthenolide to Assess the Expression of Inducible Cyclo-oxygenase and Anti-inflammatory Activity
Aims: This paper describes the expression of inducible cyclooxygenase and anti-inflammatory of medicinal herb feverfew with a synthetic parthenolide. Study Design: In vivo model to study the expression of inducible cyclo...
Pharmacokinetics and Bioequivalence Study of Two Proton Pump Inhibitor Products
Omeprazole (OPZ) efficiently suppresses acid secretion in the parietal cells of the stomach. It is widely recommended as proton pump inhibitor (PPI) in Egypt. Presence of many products containing omeprazole available in...
Validation of Titrimetric-UV Spectrophotometric Method for the Simultaneous Quantification of Paracetamol, Caffeine and Ibuprofen in Pharmaceutical Dosage Forms
Aim: The objective of this study was to develop a reliable, accurate and precise Titrimetric - UV spectrophotometric method for the assay of fixed dose combination formulations involving Paracetamol, Caffeine and Ibuprof...
Acute and Sub-acute Toxicity Studies of Ethanol Seed Extract of Raphia hookeri on Swiss Albino Rats
Aim: To evaluate the acute and sub-acute toxicities of Raphia hookeri (Rh) seed hydroethanolic extract on experimental animals. Materials and Methods: Acute toxicity study was evaluated on Swiss albino mice of both sexe...