Biochemical Changes of Ethanolic Leaf Extract Psidum Guajava of on Streptozotocin Induced Diabetic Rats
Journal Title: Public Health Open Access - Year 2019, Vol 3, Issue 1
Abstract
Background: Diabetes mellitus (or diabetes) is a chronic, lifelong condition that affects the body's ability to use the energy found in food due to absolute or relative deficiency of insulin secretion with/without varying degree of insulin resistance. The work is aimed at evaluating the biochemical changes on ethanolic leaf extract Psidum guajava of in streptozotocin induced diabetic albino rats. Methods: A total of seventy (70) ratus norvegicus rats were randomly divided into 5 groups of seven rats in each group. Group A served as normal control and received normal saline (2 ml/kg body weight). Group B was treated Streptozotocin, Group C was treated with Streptozotocin and 200mg/kg body weight of extract, D was treated with Streptozotocin and 400mg/kg body weight of extract and E was treated Streptozotocin and 5mg/kg body weight of metformin. Glucose level, levels of renal function status biomarkers and hepatic function biomarkers were determined at the end of the study (28 days). Result: Acute toxicity test revealed no mortality at maximum dose of 5000mg/kg which suggests that test substance is safe for the doses used for this study. The result in liver enzymes shows significant (p<0.05) increases in AST, ALP and ALP when compared to the normal control but showed reduction in the protein level. Group B showed significant (p<0.05) increase in urea when compared with the normal control while Group C (200mg/kg), Group D (400mg/kg) and Group E (5mg/kg metformin) showed decreases in the levels of Creatinine when compared to normal control rats. All doses of the plant extract significantly (p<0.05) mitigated change; the reversals at 200mg/kg body weight of the extract compared well (p<0.05) with their respective non- streptozotocin normal saline treatment control animals in 400mg/kg of the parameters investigated. Conclusion: Conclusively, the study demonstrated that ethanoic leaf extract of Psidium guajava can reverse the hyperglycemia associated with diabetes mellitus, when compared with a known standard drug metformin. There is need for further researchs which will be aimed at isolating and packaging the bioactive compounds responsible for this effect into finished pharmaceutical product.
Authors and Affiliations
Egege AN , Akubugwo EI and Nwaogwugwu JC
Keywords
Related Articles
- EP ID EP755502
- DOI 10.23880/phoa16000133
- Views 13
- Downloads 0
Manifestations and Strategies to Deal with Politics Science Adulteration in Community Engagement Healthcare Research
Community and Public Engagement (CPE) is increasingly acknowledged as an appropriate approach in healthcare and other policy related research. However, it is also becoming clear that community engagement necessarily invo...
Comparative Analysis of the Spread of the COVID 19 Epidemic in Berlin and New York City Based on a Computational Model
A simple calculation method is proposed based on the approximate spread model of COVID 19. A comparison of the calculation results for NYC and Berlin with observational data on the development of the epidemic in these ci...
Some Conceptual and Empirical Perspectives on Economic Growth and Development in South Asia, with Special Reference to India
Increasingly economic policies in both developing and developed during the last few decades of Liberalistion, Privatisation and Globalisation (LPG) have been focussing on achieving higher economic (GDP) growth rates. Suc...
Analysis of Interventions for Improving Cervical-Cancer Screening Uptake
Cervical-cancer is preventable through early detection of cervical intraepithelial neoplasia that heralds the disease via cervical-cancer screening, yet its mortality is still high especially in developing countries. In...
Anti-Hypertensive Medication Adherence and Associated Factors among Adult Hypertensive Patients at Dilla University Referral Hospital, South Ethiopia
Background: Hypertension is a global public health challenge that contributes to the burden of hypertensive heart disease, stroke, renal failure, premature morbidity, and mortality. The availability of effective antihype...