Biochemical changes representing oxidative stress on brain tissue due to intraabdominal hypertension in a rat model
Journal Title: Archives of Medical Science - Year 2007, Vol 3, Issue 3
Abstract
Introduction: Intraabdominal hypertension affects the central nervous system in addition to respiratory, renal and cardiovascular systems. This effect that, investigated in detail by clinical and experimental studies, is due to the increase of intracranial pressure and decrease of cerebral perfusion pressure caused by the increase of intrathoracic pressure and increase of pressure of great veins. However, no study has been found on biochemical changes on central nervous tissue due to intraabdomial hypertension. Material and methods: Thirty rats were divided into three groups containing 10 animals: sham group, study group I and study group II. In group I, intraabdominal pressure was elevated to 20 mmHg, and in group II, it was elevated to 30 mmHg for 60 minutes. Intracranial pressures (ICP) in all animals were monitored. Values of biochemical parameters including thiobarbituric acid, nitrite oxide, xanthine oxidase, protein carbonyls and protein sulfhydryl in cortical, subcortical, cerebellar and spinal cord tissues were compared with the corresponding values in sham rats. Results: Thiobarbituric acid (0.58±0.8 and 0.76±0.04 vs. 0.23±0.03, p
Authors and Affiliations
Hamit Karabekir, Feyza Guzey, Canan Balci, Yesim Guvenc, Ece Onur, Gokhan Akbulut, Mustafa Serteser
Keywords
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