BIOCHEMICAL EFFECTS OF ETHANOL LEAF EXTRACT OF MIMOSA PUDICA IN THIOACETAMIDE-INDUCED HEPATIC AND NEPHROTIC INJURY IN RATS
Journal Title: World Journal of Pharmaceutical and Medical Research - Year 2017, Vol 3, Issue 9
Abstract
The study was to investigate the biochemical effect of ethanol extract of Mimosa pudica leaf in thioacetamide-induced albino rats by using liver and kidney serum marker enzymes. After the treatment scheduled period of 21 days, the extent of nephrotoxicity and hepatotoxicity with thioacetamide (400 mg/kg bwt.) was determined. Nephroprotective and hepatoprotective activity of ethanol extract of Mimosa pudica leaf was estimated from serum samples. In this study, we assess the serum creatinine, urea, bilirubin, AST, ALT and ALP using various standard kits. Administration of thioacetamide causes an increase in the level of creatinine, urea, bilirubin, ALT, AST and ALP, which are considered as the selective biomarkers of kidney and liver injury when compared with the normal control. The present study showed decrease in the elevated levels of these enzymes. Treatment with extract of Nimosa pudica at 200 and 400 mg/kg bwt. showed a dose dependent, significant decrease in creatinine, urea, bilirubin, ALT, AST and ALP (P<0.05) when compared with the thioacetamide control group. The histopathology findings supported the results. In conclusion, the results of this study showed that ethanol leaf extract of Mimosa pudica had nephroprotective and hepatoprotective activity against thioacetamide-induced nephrotic and hepatic injury in rats.
Authors and Affiliations
Dr. Sule O. J.
Keywords
Related Articles
- EP ID EP657339
- DOI -
- Views 161
- Downloads 0
A STUDY TO ASSESS THE PRACTICES OF HEALTH WORKER REGARDING INTRAVENOUS INFUSION AMONG ADULT PATIENT RECEIVING INTRAVENOUS INFUSION THERAPY
A study was conducted with the objectives to assess the practices of health worker regarding intravenous infusion among adult patients receiving intravenous infusion at PGIMS Rohtak. Survey research approach and descript...
ANTHROPOMETRIC MEASUREMENTS IN NORMOGLYCEMIC OFFSPRING OF PATIENTS WITH T2DM ON GRADED EXERCISE
Objectives: It is uncertain if exercise could influence the occurrence of T2DM in offspring of diabetic parents. Therefore this study was designed to assess the effect of exercise on anthropometric parameters of offsprin...
ASSESSMENT OF THE SAFETY VERSUS NEPHROTOXICITY OF USNIC ACID IN RATS: BIOCHEMICAL AND HISTOPATHOLOGICAL STUDIES
Background: Nephrotoxicity is a common sequela of drug administration that has not been well investigated. Usnic acid (UA), a secondary metabolite of certain lichens, was reported to exert hepatotoxic and cardiotoxic eff...
ROLE OF FOXO PROTEIN IN OSTEOARTHRITIS AND ITS TREATMENT: GAME CHANGER IN THE FIELD OF RHEMATOLOGY
Osteoarthritis is the most common age related disease affecting older individual. Most commonly it involves weight bearing joints in human. Reduced expression of FOXO proteins has been found to be associated with develop...
THE FULL BREAST ULTRASONOGRAPHY USEFULNESS IN THE DIFFERENTIAL DIAGNOSIS OF THE BREAST TUMORS
Objectives: To promote and illustrate a new hierarchy of the Ultrasound descriptors in addition to the US BI-RADS recommendations, for improving the differential diagnosis of the breast tumors. Methods: We made retrospec...