Biochemical Evaluation of Selected Renal Indices in Women with Metabolic Syndrome in Ilesa Metropolis South Western Nigeria
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 18, Issue 5
Abstract
Aim: The aim of this study was to see the effects of metabolic syndrome on some selected renal indices for kidney biological functions. Study Design: One-factor, one control - one test group quasi - experimental design. Place and Duration of Study: Department of Chemical Pathology, Obafemi Awolowo University Teaching Hospitals Complex, Wesley Guild Hospital Unit, Ilesa, Osun State, Nigeria, between July 2015 and March 2016. Methodology: A total of eighty (80) subjects were recruited for the study, and were grouped into normotensive women (n=40), and women with metabolic syndrome (n=40). Blood samples (10 mL venous blood) and 24 hour timed urine were collected, centrifuged and stored as plasma and aliquoted urine respectively before subjection to biochemical analysis. Blood plasma and urine samples were analyzed for renal indices using standard flame photometry and Spectrophotometric methods. Results: Renal indices results revealed that Plasma (creatinine, urea, sodium and potassium) were significantly raised in women with metabolic syndrome when compared to normotensive women while significant decreases were observed in Urine (creatinine, potassium and urea) and creatinine clearance rates respectively in same comparison. However, a non-significant increase in Urine (volume and protein), as well as a non-significant decrease in urea clearance rates and urine sodium were seen in women with metabolic syndrome when compared to normotensive women. Conclusion: This work revealed that metabolic syndrome has negative effects on the renal indices investigated which were attributed to the characterizing high blood pressure and vessel dysregulation to possibly result in kidney dysfunction in its sufferer. This work thus showed that renal indices can be employed with other investigations to diagnose metabolic syndrome, prevents its medical complications and monitor treatment progress.
Authors and Affiliations
Stephen Olajide Awofadeju
Keywords
Related Articles
- EP ID EP341007
- DOI 10.9734/BJMMR/2016/26851
- Views 68
- Downloads 0
Risk Factors Associated with Children Missing the Fourth Dose of DTaP Vaccination
Background: In 2012, reported pertussis reached the highest number of cases (48,277) in the United States since 1955. Objectives: Estimate the prevalence of children who missed the fourth dose of DTaP (Diphtheria and Te...
Analysis of Human Resources for Eye Health in Ogun State of Nigeria: Progress towards Vision 2020
Aims: To conduct a situational analysis of human resources for eye health (HReH) and assess its progress towards vision 2020 goals in Ogun state of Nigeria. Study Design: A descriptive cross-sectional study. Place and Du...
Predicting Postprandial Oxidative Stress Using Serum Triglycerides Following Oral Fat Tolerance Testing
Background: The topic of postprandial oxidative stress continues to receive considerable attention, with elevations in oxidative stress biomarkers associated with human disease (e.g., insulin resistance, atherosclerosis)...
Activation of Epidermal Growth Factor Receptor (pEGFR) and Expression of Argentophilic Nucleolus Organizer Regions (AgNOR) in Seminomas
Activation of epidermal growth factor receptor (p-EGFR) is one of the triggers in the development of many malignant tumors, and the measurement of Argentophilic Nucleolus Organizer Regions (AgNOR) area is used as a marke...
Proper Medical Prescriptions and Cord Blood Harvesting Improvement at a Children’s Hospital of North Eastern Italy
A systematic harvesting of hematopoietic progenitor cells for transplant purpose in oncology begun in Friuli Venetia Giulia (FVG), a region of north east Italy, at the end of 2000. The actual economic crisis in Italy and...