Abstract

Background: Thyroid activity was produced during pregnancy, which allows the healthy individual to remain in a net euthyroid state. However, both hyper and hypothyroidism can occur in pregnant patients.1 The normal changes in thyroid activity and the association of pregnancy with conditions that can cause hyperthyroidism necessitates careful interpretation of thyroid function tests during pregnancy.2 Maternal and perinatal morbidities will be well-documented complications of pregnancy in women with thyroid dysfunction, both clinical and subclinical. A thyroid disorders was seen in about 2-5 % of pregnant women, and timely intervention can be done if detected early. Aim of study: Biochemical Evaluation of Thyroid Hormone in Pregnant women in Udaipur District of Rajasthan. Study Area: The present study will be conducted in PMCH, Udaipur. Study Design: The study will design and undertaken in the Central laboratory of PMCH Udaipur. The cases of this study compare the pregnant women or non pregnant women. Statistical Analysis: Data thus collected will be entered in Microsoft excel 2007 Worksheet in the form of master chart. These data will be classified and analyzed as per the aims and objectives. Result: When comparing each hormone between pregnancy and non pregnancy and among gestational stages, TSH concentration in normal women (2.52 ± 0.15) and pregnant women during first trimester (2.15 ± 0.04) second trimester (2.45 ± 0.03**) third trimester (0.04 ± 0.01**) showed statistically significant decline in first trimester (P < 0.001), followed by a rise which almost reached the non pregnancy level in the second trimester and third trimester. Conclusion: Prior to the introduction of screening for thyroid dysfunction in early pregnancy, it is necessary to establish trimester specific reference intervals for TSH based on ethnic background, methods of analysis, selection criteria of normal subjects, and calculation method. The reference intervals determined in this study for each trimester of pregnancy are recommended for evaluation of pregnant Indian women. These study findings are a step toward establishing trimester-specific normative data of thyroid function tests in ethnic Indian pregnant population.

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