Biochemical parameters and its association with quality of life in patients with diabetic foot ulcers
Journal Title: Medpulse International Journal of Biochemistry - Year 2019, Vol 10, Issue 1
Abstract
Background: Diabetic foot ulcer (DFU) is a serious complication of Diabetes mellitus (DM) with significant impact on the quality of life(QoL). Various biochemical parameters can play important role in evaluating QoL in DFU patients. Objective: To evaluate the health related quality of life (HRQOL) in DFU patients and its association with different biochemical parameters in a tertiary care teaching hospital. Methodology: A total of 70 DFU patients from surgery department were enrolled and their demographic and disease related parameters were recorded. They were subjected to undergo routine investigations like CBC, Hb, FBS, PP2BS, HbA1c, lipid profile and serum creatinine levels. HRQOL was evaluated using Cardiff Wound Impact Questionnaire. Association of biochemical parameters as predictors of HRQOL was statistically evaluated. Results: All patients of DFU showed deteriorated HRQOL with mean score of 42.2±15.13 in social domain, 17.12±7.43 in wellbeing, 75.33±27.06 in physical domain and total score of 146.56±45.46.FBS levels were significantly affecting all the domains like social (p=0.03), wellbeing (p=0.049), physical (p=0.04), overall quality of the life (p=0.004) and total HRQOL scores (p=0.009). HBA1c also found to be affecting all the domains including social, wellbeing, physical symptoms score, overall quality and total score(p<0.05). Decrease Hb levels significantly affected social domain (p=0.023), physical symptoms(p=0.014) and total score(p=0.059). BMI was significantly affecting social, physical symptoms, total scores and overall quality life (P<0.01). PP2BS, cholesterol and creatinine levels were not significantly associated with the QOL scores(p>0.05). Conclusion: Biochemical parameters of glycaemic control like FBS, HbA1c can serve as effective predictors of HRQOL in DFU patients. Hb levels and BMI also affects HRQOL. These biochemical parameters can be used for designing the treatment and monitoring regimen for better QOL of patients with DFUs.
Authors and Affiliations
Hiren Sanghani, Ashish kumar Agravatt, Heeya Shah, Niyati Lakhani
Keywords
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- EP ID EP559024
- DOI 10.26611/10021014
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