BIOCOMPATIBLE COMPOSITES WITH LYSOZYME BASED ON POLYURETHANE UREA WITH N-VINYL PYRROLIDONE COPOLYMER FRAGMENTS, VINYL ACETATE AND VINYL ALCOHOL
Journal Title: Вісник Одеського національного університету. Хімія - Year 2018, Vol 23, Issue 2
Abstract
A series of PUS containing a N-vinylpyrrolidone-vinyl alcohol copolymer (VP-VA) copolymer with different percentages of 4,4’-diaminodiphenylmethane (DADF) to VP-VA (30:70; 50:50; 70:30) was synthesized. On the basis of synthesized PUS, a number of composite materials containing lysozyme (the content of the medicinal substance is 1 wt%) was obtained.According to IR spectroscopic studies, immobilization of lysozyme occurs due to intermolecular hydrogen bonds (physical immobilization).Variation of the content of copolymer VP-VA in the structure of the received РUS causes changes of physical-mechanical properties. It was established that with decrease in the amount of VP-VS copolymer in the structure of PUS there is an increase in strength and relative elongation at breakIt was established that samples of PUS with fragments of VP-VS in their structure, filled with lysozyme, synthesized by the percentage ratio of DADF to copolymer VP-VS 70:30 have the best physical and mechanical properties in a series (σ = 11,5 MPa, ε = 76%). The introduction of the resulting polymer materials lysozyme leads to increased strength at break from 43% to 97%.The thermophysical properties of PUS depend on the presence of lysozyme in their composition.When introducing into the structure PUS of the enzyme , an increase in the glass transition temperature and a decrease in the heat capacity jump due to the decrease in the segmental mobility of the macromolecules. It is established that the studied systems are single-phase.The method of culture of tissues was founding that all composite materials are biocompatible and non-toxic. For experimental samples with lysozyme, more active growth of fibroblast cells was observed.
Authors and Affiliations
K. V. Stashenko, T. V. Rudenchyk, R. A. Rozhnova, N. A. Galatenko, L. F. Narazhaiko
Keywords
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- EP ID EP493703
- DOI 10.18524/2304-0947.2018.2(66).132042
- Views 78
- Downloads 0
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