BIODEGRADATION OF PARACETAMOL BY NATIVE FUNGAL SPECIES INHABITING WASTEWATER OF A PHARMACEUTICAL FACTORY IN SANA’A, YEMEN
Journal Title: Universal Journal of Pharmaceutical Research - Year 2017, Vol 2, Issue 6
Abstract
Lozenges are the flavoured solid, unit dosage medicated dosage forms usually in the sweetened base intended to be sucked and held in the mouth or pharynx containing one or more medicaments. Lozenges were developed in 20th century and is still under commercial production. These are medicated confections designed for local as well as systemic therapy. Carbamazepine (CBZ) is an anticonvulsant drug used in the treatment of epilepsy and neuropathic pain. It is used in schizophrenia along with other medications. In the present study an attempt has been made to prepare and evaluate the sugar based medicated Carbamazepine lozenzes to improve bioavailability and increase patient compliance specially for those patients who have difficulty in swallowing. The lozenges were prepared using sucrose as base; HPMC K4M, methyl cellulose were used as polymers. Eudragit was used as taste masking agent. Formulations were prepared by heating and congealing method on laboratory scale All the formulations prepared were subjected to various physicochemical parameters like hardness, friability, weight variation, drug content and in vitro dissolution studies. Stability studies of selected formulations of batch CL4 were also carried out at 40/75% relative humidity for 6 months for a period of six months. There wasn’t any substantial interaction between the drugs, flavor and color and other parameters and the prepared formulations were found to be stable.
Authors and Affiliations
Wadhah Hassan Edrees, Qais Yusuf Abdullah, Khalid Mohamed Naji, Ali Gamal AL-Kaf
Keywords
Related Articles
- EP ID EP36427
- DOI https://doi.org/10.22270/ujpr.v2i6.R7
- Views 301
- Downloads 0
PREVALENCE OF DYSLIPIDEMIA AND ITS ASSOCIATION WITH DISEASE ACTIVITY IN PATIENTS WITH RHEUMATOID ARTHRITIS IN SULAIMANI GOVERNORATE
Rheumatoid arthritis is a systemic inflammatory disease characterized by chronic and erosive polyarthritis it is the most common inflammatory arthritis, affecting from 0.5-1% of the general population. Dyslipidemia is...
PREVALENCE OF LEPTOSPIROSIS AMONGST SLAUGHTERHOUSE WORKERS AND BUTCHERS IN SANA'A CITY-YEMEN
Zoonotic infections can be work-related risks to people who labor in nearby connection with animals. The goals of present study were to find out the prevalence of leptospira antibodies and impact factors of leptospirosis...
EFFECT AND MECHANISM OF TRADITIONAL CHINESE MEDICINE HUOLOU GUKANG PILL COMBINED WITH SIMVASTATIN ON STEROID-INDUCED NECROSIS OF FEMORAL HEAD
Aim of present study was to explore the effect and mechanism of traditional Chinese medicine HuoLou Gukang pill combined with simvastatin on steroid-induced necrosis of femoral head. A total of 130 patients with stero...
DENDRIMERS: A NOVEL TOOL FOR DRUG DELIVERY AND TARGETING
Dendrimers are hyper-branched macromolecules having tree like structure, consisting of a core molecule and alternating layers of monomers. Due to their unique architecture these have improved physical and chemical prope...
PRESCRIPTION PATTERN OF ANTI-HYPERTENSIVE DRUGS IN A TERTIARY CARE HOSPITAL IN KERALA AND ADHERENCE TO JNC-8 GUIDELINES
Hypertension is a leading contributor to the global burden of cardiovascular morbidity and mortality. Worldwide prevalence is continuing to increase. Treatment for hypertension is constantly evolving and many new drugs a...