BIOENHANCED TRANSDERMAL DELIVERY SYSTEM OF A POORLY WATER SOLUBLE
Journal Title: Mintage journal of pharmaceutical and medical sciences - Year 2016, Vol 5, Issue 4
Abstract
Objective: The absolute bioavailability of atorvastatin, a selective, competitive inhibitor of HMG-CoA reductase, is very low. The nanoemulsion gel formulation offers better platform for delivering a drug with poor oral bioavailability. Methods: In this study, we prepared the nanoemulsion gel which contained atorvastatin loaded sunflower oil and using Carbopol 940 polymer as gelling agent. Cumulative percentage of drug release was determined from the in vitro drug release study. Results: Cumulative drug release data showed sustained release of the drug up to 8 hours. The ex-vivo permeation study was performed on rat skin. In vivo study was carried out using animal model for evaluating anti-hypercholesterolemic activity. In the in vivo studies, atorvastatin nanoemulsion gel demonstrated a marked decreasing effect in total cholesterol (TC) level, low density lipoprotein (LDL) level and (TG) triglycerides level. High density lipoprotein (HDL) level was significantly increased by atorvastatin nanoemulsion gel. Conclusion: Thus, transdermal nanoemulsion gel of atorvastatin was found to be an effective formulation in treating hypercholesterolemia.
Authors and Affiliations
k. pramod, j. valsalakumari, m. nagajyothi
Keywords
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