BIOENHANCED TRANSDERMAL DELIVERY SYSTEM OF A POORLY WATER SOLUBLE
Journal Title: Mintage journal of pharmaceutical and medical sciences - Year 2016, Vol 5, Issue 4
Abstract
Objective: The absolute bioavailability of atorvastatin, a selective, competitive inhibitor of HMG-CoA reductase, is very low. The nanoemulsion gel formulation offers better platform for delivering a drug with poor oral bioavailability. Methods: In this study, we prepared the nanoemulsion gel which contained atorvastatin loaded sunflower oil and using Carbopol 940 polymer as gelling agent. Cumulative percentage of drug release was determined from the in vitro drug release study. Results: Cumulative drug release data showed sustained release of the drug up to 8 hours. The ex-vivo permeation study was performed on rat skin. In vivo study was carried out using animal model for evaluating anti-hypercholesterolemic activity. In the in vivo studies, atorvastatin nanoemulsion gel demonstrated a marked decreasing effect in total cholesterol (TC) level, low density lipoprotein (LDL) level and (TG) triglycerides level. High density lipoprotein (HDL) level was significantly increased by atorvastatin nanoemulsion gel. Conclusion: Thus, transdermal nanoemulsion gel of atorvastatin was found to be an effective formulation in treating hypercholesterolemia.
Authors and Affiliations
k. pramod, j. valsalakumari, m. nagajyothi
Keywords
Related Articles
- EP ID EP438918
- DOI -
- Views 139
- Downloads 0
RELIGIOUS ORIENTATION AND ITS EFFECTIVE FACTORS AMONG MEDICAL SCIENCES STUDENTS
Aim: Having information about how religious orientation is in medical sciences students, is necessary to improve it. Thereby, based on the limited studies in this regard, the present study was designed with the aim of st...
LIMITED BUT IMMERGING: INFORMATION TECHNOLOGY IN PHARMACY
Objective: In contemporary years, the quantity of medicine and drug treatments has larger extremely that are quite often more strong and extra selective and in addition, the literature relating to medicines has extended...
COMPARATIVE STUDY OF ANTIBACTERIAL ACTIVITY BETWEEN THE CITRUS LIMON (LEMON) & CITRUS AURANTIUM (BITTER ORANGE) EXTRACTS ON PSEUDOMONAS AERUGINOSA ISOLATES FROM BURNS INFECTIONS
Aims: This study to the compared antibacterial activity of the Citrus Juices (lemon & bitter orange) in vitro by the well diffusion assay against Pseudomonas aeruginosa isolated from burned patients in Baghdad, Iraq. Mat...
CHEATING IN B.PHARMACY EXAMINATIONS – RATIONALE, CONSEQUENCES AND MEASURES TO CURB THIS MENACE
Context: Cheating in examination is now-a-days, become a common phenomenon, all over the world. So, B.Pharmacy is not a different case. This is also a problem or rather menace in B.Pharmacy course also. Objectives: Chea...
RP-HPLC METHOD FOR DETERMINING THE LEVELS OF GUAIPHENESIN AND PHENYLEPHRINE IN PHARMACEUTICAL DOSAGE FORMS
A simple, precise and accurate reverse phase high performance liquid chromatographic method was developed for the simultaneous estimation of guaiphenesin and phenylephrine in their tablet dosage form. The chromatographic...