Bioequivalence evaluation of norfloxacin tablets based on in vitro – in vivo correlation
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2011, Vol 24, Issue 4
Abstract
Present study was designed to establish in-vitro and in-vivo correlation (IVIVC) of two immediate release tablet formulations of 400mg Norfloxacin [Drug A as test and Drug B as reference]. Dissolution study was conducted in 0.1 N HCl using USP apparatus II. In-vivo evaluation was carried out in 18 healthy humans according to a single dose, two-sequence, and cross-over randomized with a wash-out period of one week. After dosing, serial blood samples were collected for a period of 10 hours. Plasma harvested from blood, was analyzed for norfloxacin by a sensitive, reproducible and accurate HPLC method. Various pharmacokinetic parameters were determined from plasma concentrations for both the formulations. Non-significant difference was found for test/reference ratio of these parameters and the value of F was found to be 0.99 which is in good agreement with the limits given in FDA and WHO guidelines for such parameters. Difference factor (f1), similarity factor (f2) and level A IVIVC were evaluated showing that drug A is bioequivalent to drug B.
Authors and Affiliations
Sonia Khiljee, Mahmood Ahmad, Ghulam Murtaza, Asadullah Madni, Naveed Akhtar, Muhammad Akhtar
Keywords
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