BIOLOGICAL ACTIVITIES OF ARREDOUL JAUNE, A PHYTOMEDICINE BASED ETHANOL EXTRACT FROM FRESH ROOTS OF PENTADIPLANDRA BRAZZEANA BAILL. (PENTADIPLANDACEAE) USED AS AN ANTIDIARRHOEAL DRUG IN KISANGANI-DEMOCRATIC REPUBLIC OF CONGO
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2018, Vol 5, Issue 1
Abstract
Arredoul jaune, a phytomedicine based ethanol extract from the roots of Pentadiplandra brazzeana (Pentadiplandraceae), its soluble fractions, crude saponins and total alkaloids extract were submitted to a broad biological screening including antimicrobial, antiamoebic and spasmolytic activities which can justify its use as an antidiarrhoeal drug. Results indicated that all samples were significantly active in each assay with varying magnitudes. Arredoul jaune exhibited good antibacterial and bactericidal activities against all selected bacteria including Bacillus subtilis, Escherichia coli, Salmonella entertidis, Shigella dysenteria, Staphylococcus aureus, Shigella flexneri and Salmonella thyhimurium with MIC and MBC values < 100 μg/ml. It also displayed strong antiamoebic activity with minimal amoebicidal concentration (MAC) of 5.32 ± 0.02 μg/ml and produced more than 75% inhibition of acetylcholine (Ach) and depolarising solution rich in KCl-induced guinea-pig ileum contractions. Chroroform and ethylacetate soluble fractions from the partition of Arredoul jaune exhibited good antibacterial and bactericidal activities with MIC and MBC < 100 μg/ml, good and strong antiamoebic activity with MAC value of 15.21 ± 0.07 and 8.25± 0.12 μg/ml respectively. They produced more than 70% inhibition of both agonists- induced contractions of ileum guinea-pig. n-butanol fraction showed good antibacterial activity against Salmonella enteritidis, Shigella dysenria and S. flexneri (MIC and MBC < 100 μg/ml) while the residual aqueous phase exhibited moderate or low activity against selected bacteria according to the case (MIC or MBC = 15 or 250 μg/ml). They exhibited moderate antiamoebic activity (MAC > 10 μg/ml) and produced more than 64% inhibitions of both agonists-induced guinea-pig ileum contractions. Total alkaloids extract displayed good antibacterial and bactericidal activities with MIC and MBC < 100 μg/ml, strong antiamoebic activity with MAC value of 3.57 ± 0.05, μg/ml and produced more than 76% inhibition of both agonists-induced guinea-pig ileum contractions. Crude saponins showed only weak antimicrobial activity, moderate antiamoebic activity (MAC = 12.47 ± 0.47 μg/ml and produced more than 60% inhibition of both agonist-induced guinea-pig ileum contractions. These results can partly justify and support the use of Arredoul jaune in courant live for the treatment of diarrhoea whatever the origin of the disease.
Authors and Affiliations
Dr. Cimanga K. R.
Keywords
Related Articles
- EP ID EP635018
- DOI -
- Views 126
- Downloads 0
ANTIBIOTICS SUSCEPTIBILITY PATTERNS OF STAPHYLOCOCCUS AUREUS IN CLINICAL ISOLATES FROM MAITAMA DISTRICT HOSPITAL, ABUJA, NIGERIA
Staphylococcus aureus is a major pathogen causing a variety of infections ranging from mild skin infections to life threatening systemic illness. Antibiotic resistance by Methicillin Resistant Staphylococcus Aureus (MRSA...
EVALUATION OF CYTOTOXIC ACTIVITY OF CHORDA FILUM FROM THE LEBANESE COAST AGAINST MCF-7 CANCER CELL LINE
The discovery of cancer drugs and the identification of agents that effectively destroy cancer cells or stop their growth without toxicity to normal cells, and reduce the opportunity for the development of drug resistanc...
FREQUENCY OF HUMAN LEUCOCYTES ANTIGEN (HLA) B LOCUS IN UMBILICAL CORD BLOOD OF DIFFERENT ETHNIC SUBJECTS IN PORT HARCOURT
The HLA system is known to be the most polymorphic genetic loci in humans. Distribution and frequencies of HLA alleles are highly variable among different human ethnic groups. The aim of the study was to determine the HL...
A REVIEW ON ANTICANCER POTENTIAL OF THIAZOLE-HETEROCYCLIC HYBRID COMPOUNDS
In anticancer drugs, hybrid structure are of great therapeutic interest due they can potentially overcome most of the pharmacokinetic drawbacks. Thiazole-heterocyclic hybrid derivatives are another class of heterocyclic...
DRUG UTILIZATION PATTERN IN SICKLE CELL DISEASE IN HEMATOLOGY UNIT OF UNIVERSITY OF PORT HARCOURT TEACHING HOSPITAL: A 5-YEAR RETROSPECTIVE STUDY
Background: Sickle cell disease (SCD) is an important public health problem in Nigeria and about 2% of all newborn are born with the disease. The treatment of the symptoms of SCD includes adequate hydration, blood transf...