Biological and Clinical Spectrum of Piceatannol – A Hydroxylated Analogue of Resveratrol: A Phytochemical Review.
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2012, Vol 1, Issue 3
Abstract
Resveratrol (3, 4’, 5-trans-trihydroxystilbene), a naturally occurring stilbene, is considered to have a number of beneficial effects, including anticancer, anti-aethrogenic, anti-oxidative, anti-inflammatory, anti-microbial and estrogenic activity. Piceatannol (3, 3', 4, 5'-trans-trihydroxystilbene), a naturally occurring hydroxylated analogue of resveratrol, is less studied than resveratrol but displays a wide spectrum of biological activity. Piceatannol has been found in various plants, including grapes, passion fruit, white tea, and Japanese knotweed. Besides antioxidative effects, piceatannol exhibits potential anticancer properties as suggested by its ability to suppress proliferation of a wide variety of tumor cells, including leukemia, lymphoma; cancers of the breast, prostate, colon and melanoma. Although piceatannol has been shown to induce apoptosis in cancer cells, there are examples of its anti-apoptotic pro-proliferative activity. Piceatannol inhibits Syk kinase, which plays a crucial role in the coordination of immune recognition receptors and orchestrates multiple downstream signaling pathways in various haematopoietic cells. Piceatannol also binds estrogen receptors and stimulates growth of estrogen-dependent cancer cells. The pharmacological properties of piceatannol, especially its antitumor, antioxidant, and anti-inflammatory activities, suggest that piceatannol might be a potentially useful nutritional and pharmacological biomolecule; however, more data are needed on its bioavailability and toxicity in humans. The aim of present article is to provide in depth knowledge about clinical and biological activity of Piceatannol. An attempt is also made to focus on various health effects of Piceatannol and brief description of Piceatannol.
Authors and Affiliations
Satyanand Tyagi*| President, Tyagi Pharmacy Association & Scientific Writer (Pharmacy), Chattarpur, New Delhi, India-110074., Patel Chirag J| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020., Raghvendra| Department of Pharmaceutics, Aligarh College of Pharmacy, Aligarh, U.P, India-202001.
Keywords
Related Articles
- EP ID EP1579
- DOI -
- Views 391
- Downloads 27
Application of omics in personalized oral health care: A paradigm shift
Periodontal disease and Dental caries are the most common oral diseases in adult populations worldwide and is a major public health concern due to its substantial cost to the oral health care system. During recent years...
Transcriptional R loops and their significance in neurodegenerative disease and possible elimination by specific carrier mediated microRNA techniques; importance for clinical therapeutics
The transcription process has been shown to stimulate both mutation and recombination in many living beings from bacteria to mammals, but the mechanisms underlying this phenomenon are still largely unknown. A particularl...
SEROFREQUENCY OF HEPATITIS D VIRUS AMONG HEPATITIS B VIRUS INFECTED PATIENTS ATTENDING TO TALODI HOSPITAL, SOUTH KORDOFAN STATE, SUDAN.
Background: Hepatitis Delta Virus (HDV) infects only patients that are already infected by hepatitis B virus (HBV) because this is sub satellite virus which depends on and propagate only in the presence of HBV. HDV cause...
COMPARITIVE EVALUATION OF TISSUE GLYCOGEN AND SALIVARY PH IN CHRONIC GINGIVITIS AND CHRONIC PERIODONTITIS PATIENTS
BACKGROUND: The inflammation of gingiva is known as gingivitis with microorganisms present in the gingival sulcus, being the major cause for this pathologic condition. Periodontitis is a chronic inflammatory disease whic...
A STUDY ON BLOOD BILIRUBIN LEVELS IN TERTIARY CARE CENTRE OF KUMAUN REGION (UTTARAKHAND) INDIA.
Jaundice occurs in most newborn infants. Most jaundice is benign, but because of the potential toxicity of bilirubin, newborn infants must be monitored to identify those who might develop severe hyperbilirubinemia and,...