BIOLOGICAL EVALUATION OF 2-ARYLIDENE-4-(METHOXYPHENYL)BUT-3-EN-4-OLIDES
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2015, Vol 4, Issue 5
Abstract
A series of 2-Arylidene-4-(methoxyphenyl)but-3-en-4-olides were screened against Pheretima posthuma earthworm for anthelmintic activity. The in vitro effects of compounds were evaluated at a concentration of 2mg/mL and time taken by the compounds to paralyze and subsequently kill the worms was recorded. Butyrolactone derivatives exhibited moderate to good anthelmintic activity but among all tested compounds, compound II, 2-(3,4,5-trimethoxy-benzylidene)-4-(methoxyphenyl)but-3-en-4-olide, was found to be the most potent against Pheretima posthuma. The anthelmintic activity of compound II was observed to be comparable with positive control albendazole in terms of paralytic and lethal time.
Authors and Affiliations
Mohammad Maaz| Faculty of Medicine (Unani), Jamia Hamdard (Hamdard University), New Delhi-110062, India, Aftab Ahmad| Health Information Technology Department, Jeddah Community College, King Abdulaziz University, Jeddah-21589, KSA, Shah Alam Khan| Dept of Pharmacy, Oman Medical College, PO Box 620, PC 130, Muscat, Sultanate of Oman, Asif Husain*| Dept of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi-110062, India
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