BIOLOGICAL EVALUATION OF IN VIVO DIURETIC AND ANTIUROLITHIATIC ACTIVITIES OF LEAF EXTRACTS OF MELOCHIA CORCHORIFOLIA
Journal Title: International Journal of Pharmacognosy - Year 2017, Vol 4, Issue 7
Abstract
The present study was investigated to establish the diuretic and antiurolithiatic activities of chloroform and ethanolic leaf extract of Melochia corchorifolia. The chloroform and ethanolic leaf extract were administered to experimental rats orally at a dose of 200 mg/ kg and 400 mg/kg. Furosemide (5 mg/kg) was used as reference standard for diuretic activity. The parameters measured for diuretic activity was total urine volume; urine electrolyte concentrations such as sodium, potassium, chloride and bicarbonates. In in-vitro antiurolithiatic activity, Calcium oxalate crystallization was induced by the addition of 0.01M sodium oxalate solutions in synthetic urine. The effect of chloroform and ethanolic leaf extract of Melochia corchorifolia (100, 200 and 500 μg/ml) was studied by time course measurement of absorbance at 620 nm for ten minutes by means of a spectrophotometer. Both the extracts show good in-vitro antiurolithiatic activity. In in-vivo antiurolithiatic activity, urolithiasis was induced in male rats by administering ethylene glycol (0.75% v/v) in drinking water for 28 days and the parameters such as oxalate, calcium and phosphate were estimated in urine. Serum creatinine, calcium and uric acid were also estimated. Treatment with the leaf extract of Melochia corchorifolia restored all biochemical, urinary parameters. The results obtained justified the importance of the leaf extract of Melochia corchorifolia as a diuretic and antiurolithiatic agent.
Authors and Affiliations
M. N. Palaksha et al.
Keywords
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