Biological therapy for pediatric ulcerative colitis
Journal Title: Postępy Nauk Medycznych - Year 2014, Vol 27, Issue 3
Abstract
Ulcerative colitis is a chronic inflammatory bowel disease of unknown etiology. Actually, the main pathogenic role is attributed to pro-inflammatory cytokines, the major one is Tumour Necrosis Factor alpha (TNF-α). The advances in understanding the pathogenesis of inflammatory bowel disease have led to the introduction of new therapeutic options, biological agents. Till now U.S. Food and Drug Administration (FDA) approved three monoclonal antibodies against TNF-α to treat adults with moderate to severe ulcerative colitis with an inadequate response to conventional therapy, or who are intolerant, or have medical contraindications for such therapy. These are: infliximab, adalimumab and golimumab. Only infliximab has been approved by the agency to treat children, nonetheless adalimumab is also used in treatment of pediatric patients with ulcerative colitis. The purpose of this review is to summarize the current knowledge on the use of biologics in pediatric ulcerative colitis. Currently, this new therapeutic options are the integral part of the pediatric ulcerative colitis treatment algorithm and with time probably will be used more extensively.
Authors and Affiliations
Anna Wiernicka, Maciej Dądalski, Monika Szychta, Grzegorz Oracz, Jarosław Kierkuś
Keywords
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