Biology of Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL) and Osteoprotegerin (OPG) in Periodontal Health and Disease - A Review
Journal Title: People's Journal of Scientific Research. - Year 2014, Vol 7, Issue 1
Abstract
Periodontitis is a destructive disease that targets tooth-supporting structures through complex and multifactorial pathogenic processes. Alveolar bone destruction, a hallmark of periodontitis progression and one of the major causes of tooth loss in human, is mediated by the host immune and inflammatory response to microbial challenge. The discovery of the receptor activator of nuclear factor-kappa B (RANK)/ RANK ligand (RANKL)/osteoprotegerin (OPG) axis has improved the knowledge of bone metabolism regulation. The RANKL/RANK interaction is needed for differentiation and maturation of osteoclast precursor cells to activate osteoclasts and for the survival of mature osteoclasts. Osteoprotegerin is the naturally occurring inhibitor of osteoclast differentiation. It binds to RANKL with high affinity and blocks RANKL from interacting with RANK. The RANKL/OPG ratio is increased in periodontitis compared to healthy individuals, suggesting that this molecular interaction may be important in modulating local bone loss. In recent decades, studies on cellular and molecular mechanisms of bone loss in periodontitis have suggested that the use of host modulation agents is an important adjunctive therapy to scaling and root planning. This line of investigation is expected to help in the development of new therapeutic approaches to stop progressive bone resorption induced by oral bacterial challenge.
Authors and Affiliations
V. A. Patil, , M. H. Desai
Keywords
Related Articles
- EP ID EP157400
- DOI -
- Views 72
- Downloads 0
Efficacy of Snodgrass Urethroplasty Using De- epithelialised Flap
This research included 30 cases of hypospadias admitted in Maharani Laxmi Bai Medical college, Jhansi between January 2014 to June 2015 to study the effects of water proofing in hypospadias repair by Snodgrass urethropl...
L-Asparaginase: A Promising Enzyme for Treatment of Acute Lymphoblastic Leukiemia
Asparaginases are known to be the cornerstone for treatment of acute lymphoblastic leukemia (ALL) and are used for treatment in all pediatric regimens as well as in the majority of adult treatment protocols. Clinical hyp...
Post Auricular Flaps in Helical Rim Defect
Human ear is a complicated structure with closely adherent anterior skin. Choosing the best technique for its repair is a challenge. The advantage and disadvantage of each procedure is to be cautiously and judiciously w...
Perinatal Outcome in Growth Retarted Babies Born to Normotensive and Hypertensive Mothers: A Prospective Study
Pregnancy induced hypertension is one of the common condition of unknown etiology which increases the maternal and perinatal morbidity and mortality. The present study was carried out to find the perinatal outcome in int...
Maternal Risk Factors of Caesarean Delivery in a Tertiary Care Hospital in Central India: A Case Control Study
One of the most alarming features of modern obstetrics is the relentless increase in c-section rates. Medical, institutional, legal, psychological and socio-demographic factors play a contributing role. Although c-sectio...