Biomarkers Score for Patients with Mitral Stenosis: A useful conjunction with Wilkins’s Score for Early Intervention
Journal Title: Heart Research – Open Journal - Year 2015, Vol 2, Issue 4
Abstract
Objective: We proposed a novel new insight independent score of Mitral Stenosis (MS) based on elevated biomarkers. Subjects and Methods: One hundred sixty-eight patients with MS candidate for Percutanous balloon valvuloplasty (PBMV) were included in the study. Brain Natriurectic Peptide (BNP), Tenascin-C (TN-C), copeptin and high-sensitive C-reactive protein (hs-CRP) were measured before PBMV. The cut-off value of each biomarker for prediction of systolic pulmonary artery pressure >50 mm Hg was calculated. Two points were given to a value ≥cut-off value and one point if less. Summation of points gave the biomarkers score. Results: A biomarker score cut-off value ≥5.2 had a sensitivity of 83.6%, a specificity of 82.9% (AUC=0.85), in predicting cardiac events after successful PBMV. The Wilkins’s score of ≥6.5 had a sensitivity of 73.5%, a specificity of 79.2% (AUC=0.80). The conjunction of Wilkins’s score with biomarker score have higher predicting power (AUC=97%). The correlation co-efficient of biomarker score was (r=0.755), greater than that of the Wilkin’s score (r=0.613). The combined biomarkers and Wilkins’s score showed the strongest correlation with cardiac events (r=0.911). In multiple regression analysis, the regression co-efficient of biomarker score versus Wilkin’s score was (0.595 versus 0.364), and the combined scores had the strongest powerful independent predictor of cardiac events (r=0.825). Conclusions: In patients with MS especially asymptomatic patients, biomarker risk score that included BNP, tenacin-c, copeptin and hs-CRP and, had a good correlation with clinical outcomes after successful PBMV, and the conjunction of the biomarkers score and Wilkin’s score provided higher prognostic value.
Authors and Affiliations
Ragab Abdelsalam Mahfouz
Keywords
Related Articles
- EP ID EP556913
- DOI 10.17140/ HROJ-2-121
- Views 113
- Downloads 0
Interpretation of Heart Sound Signal through Automated Artifact-Free Segmentation
Purpose: Digital recording of heart sounds commonly known as Phonocardiogram (PCG) signal, is a convenient primary diagnostic tool for analyzing condition of heart. Phonocardiogram aids physicians to visualize the acoust...
An Emergent Echo-Guided Apical Pericardiocentesis for Cardiac Tamponade in a Patient with only the Left Lung
A 74 years old man with previous right pneumonectomy was admitted with cardiac tamponade. Pericardiocentesis was attempted through sub-xiphoid approach but was not feasible. Therefore, second echo-guided pericardiocentes...
Short-term Cardio-Vascular Risk Score Changes in Type 2 Diabetic Patients on Empaglifozin: A Real-Life Clinical Experience
Objective: The aim of the study was to test both efficacy and safety of empaglifozin in type 2 diabetic out patients followed-up within a single institution. Materials and Methods: One hundred seventy-eight consecutive p...
Carcinoid Heart Disease and Review of Literature
Carcinoid Heart Disease (CHD) is one of the rare causes of acquired valvular heart disease. CHD develops as a systemic manifestation of metastatic neuroendocrine tumors (NETs). When these tumors metastasize to the liver,...
The PLATFORM Trial: An Insight into the Improved Value of Using FFRCT for Reduction of Invasive Angiographic Procedures
Coronary CT Angiography (CCTA) has been widely used as a reliable non-invasive modality for the diagnosis of Coronary Artery Disease (CAD) due to its improved spatial and temporal resolution.1-5For patients with low to i...