Biomechanical Bases of Forecasting Occurrence of Carotid Atherosclerosis
Journal Title: Annals of Circulation - Year 2016, Vol 1, Issue 1
Abstract
The purpose of this study was to investigate changes of the effective and shear stresses level on the surface of atherosclerotic plaques in comparison with the healthy vessel wall, as well as distribution of the hemodynamic forces. Two software modules were used: ANSYS CFX for simulating blood flow, and Structural (Mechanical) for simulating the stress-strain state of the walls. Geometric models of vessels were built on basis of healthy and diseased vessels casts in the CAD system SolidWorks. We discovered the phenomenon of stress-strain state of atherosclerotic plaques: soft plaque is different from the rigid, which creates conditions for plaque rupture under the influence of blood pressure and shear stress. The stress difference between rigid and unchanged vessel with carotid stenosis creates additional flows and vortexes, growing in proportion to the increase of the plaque size. In addition, such state can be directly related to the development of mural thrombosis. Analysis of the blood flow velocities vector field and pattern of streamlines in the external carotid artery demonstrates a complete blockage of the vessel. Vortex and congestion area formation in the ampoule of internal carotid artery creates conditions for further plaque progression.
Authors and Affiliations
Yulia Kuzyk, DV Ivanov, AV Dol
Keywords
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- EP ID EP558543
- DOI 10.17352/ac.000001
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Biomechanical Bases of Forecasting Occurrence of Carotid Atherosclerosis
The purpose of this study was to investigate changes of the effective and shear stresses level on the surface of atherosclerotic plaques in comparison with the healthy vessel wall, as well as distribution of the hemodyna...