Biophysical Biomarkers of The Fertile Window in Sub-Fertile Women: Individual Approach

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Biophysical Biomarkers of The Fertile Window in Sub-Fertile Women: Individual Approach

Journal Title: Interventions in Gynaecology and Women’s Healthcare - Year 2018, Vol 2, Issue 4

Abstract

Introduction: Fertility signals from the fertile window can improve the prediction, detection and diagnosis of the fertile phase in subfertile woman. The effectiveness of the use of such signs in subfertile women can help to get pregnant. This article includes subfertiles women who incorporated fertility biomarkers of cervical secretion fertility, in the range of left kurtosis of the curve of the fertile phase. Material and Method: This report includes 30 sub-fertile women with an average age of 34.3 years (sem 0.96); range: (26-46 years). An individual approach was adopted through the evolution of biophysical parameters of viscoelasticity and transparency of cervical secretion. The progression of the biomarkers was located in the fertile window, with the purpose of improving the perception in the recognition of the evolution of the biophysical properties of the cervical mucus. Results: Pregnancy was obtained in 33% of the cases, in which 27% (8/30) were women under 35 years of age. Pregnancy was obtained in two cases in women older than 35 years. The success rate to achieve a pregnancy was higher in the group of women under 35 years of age. Ten cases of patients with male factor were included, achieving two cases of pregnancy equivalent to 6.6% of the sample in the group of patients under 35 years of age. Conclusion: Subfertile couples with risk factors such as age, dilation in time to look for a pregnancy, and sperm of poor quality, may be candidates to consider advancing gestational desire, or consider protocols that help to detect the fertile window through observation of the evolutionary pattern of cervical secretion. The American Society for Reproductive Medicine has defined the length of the fertile period when the first day oestrone-3- glucuronide (E3G) is detected in urine, to the second day after the luteinizing hormone (LH) peaks. This period usually varies between 7 days in fertile people [1]. Actually, most studies define the period of greatest fertility since six days before ovulation until one day after ovulation. The change from infertile days to the most fertile days in the follicular phase of the menstrual cycle occurs during this interval, which is determined by the gradual development of the dynamic follicular progress of the ovulation [2,3]. This interval is different among sub-fertile couples; however, a good correlation also has been observed between biomarkers, at the beginning, and the end of the fertile period in cycles of sub-fertile women with regular and irregular menstrual periods, without specific pathology [4]. The decision to detect the fertile window in subfertile patients depends on the spontaneous pregnancy possibilities proven effectiveness [5]. In sub-fertile couples, the fertile window length varies, from the first day of normal sperm-mucus interaction to the ovulation period. The objective of this cases-study focused primarily on couples in order to increase the efficiency in the estimating of the time-specific of the fertile window to help to improve pregnancy probabilities.

Authors and Affiliations

Murcia Lora JM

Keywords

Fertile Window Sub-Fertility Sterility Fertile Biomarkers Cervical Secretion Ovulation Journal of Gynaecology Journal of Obstetrics and Gynaecology Obstetrics & Gynecology Journals Journal of Women's Health Care Journal of Gynecology and Women's Health Gynecology and Women's Health Journal of Women's Health Care Gynecology Journals lupine publishers journals

EP ID EP574550
DOI 10.32474/IGWHC.2018.02.000144
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